MLF2 Antibody (B-6): sc-166874
- MLF2 Antibody (B-6) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against amino acids 1-130 mapping at the N-terminus of MLF2 of human origin
- recommended for detection of MLF2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- m-IgGκ BP-HRP is the preferred secondary detection reagent for MLF2 Antibody (B-6) for WB and IHC(P) applications. This reagent is now offered in a bundle with MLF2 Antibody (B-6) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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MLF2 Antibody (B-6) is a mouse monoclonal IgG2b antibody that detects myeloid leukemia factor 2 (MLF2) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MLF2 plays a significant role in normal hematopoietic differentiation and is involved in switching between erythroid and myeloid lineages, essential for proper blood cell development. This 248-amino acid protein is ubiquitously expressed, with highest levels found in testis, ovary, skeletal muscle, heart, kidney, and colon tissues, while lower levels appear in spleen, thymus, and peripheral blood leukocytes. MLF2′s function involves regulation of gene expression during hematopoiesis, vital for maintaining healthy blood cell populations and preventing disorders such as leukemia. MLF2 shares 40% sequence identity with myeloid leukemia factor 1 (MLF1) and is located on chromosome 12p13, a region frequently associated with translocations in acute leukemias of both lymphoid and myeloid origins. Despite this chromosomal region′s association with leukemias, no structural alterations in MLF2 locus have been identified in patients with 12p translocations, highlighting MLF2′s complex role in cancer biology.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MLF2 Antibody (B-6) | sc-166874 | 200 µg/ml | $322.00 | |||
MLF2 Antibody (B-6): m-IgGκ BP-HRP Bundle | sc-534835 | 200 µg Ab; 40 µg BP | $361.00 |