Misato Antibody (F-8): sc-393391

Misato Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects Misato in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Misato plays a crucial role in cellular processes, particularly in the regulation of chromosomal segregation during cell division. This function is vital as improper chromosomal segregation can lead to aneuploidy, which is associated with various developmental disorders and cancers. Misato (F-8) antibody recognizes a protein containing a unique combination of peptide motifs found in alpha-, beta-, and gamma-tubulins, as well as a motif related to myosin heavy chain proteins, highlighting Misato′s multifaceted role in cellular dynamics. Notably, null mutations at the misato locus in Drosophila melanogaster result in significant developmental defects, including irregular chromosomal segregation, reduced imaginal disk tissue, and decreased brain size, ultimately leading to larval lethality. Misato (F-8) monoclonal antibody serves as an essential tool for researchers investigating the intricate mechanisms of cell division and the implications of misregulated protein interactions in developmental biology and disease.

The preferred Misato antibody is Misato Antibody (E-10): sc-390638.