Misato Antibody (122.321): sc-13568

Misato Antibody (122.321) is a mouse monoclonal IgG2a antibody that detects Misato protein in Drosophila melanogaster through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Misato plays a crucial role in cellular processes, particularly in ensuring proper chromosomal segregation during cell division. Misato protein contains a unique combination of peptide motifs characteristic of alpha-, beta-, and gamma-tubulins, as well as a motif associated with myosin heavy chain proteins, highlighting its multifaceted role in cellular dynamics. The significance of Misato is underscored by the consequences of null mutations at its locus, which lead to irregular chromosomal segregation and result in larvae exhibiting reduced imaginal disk tissue and brain size, ultimately causing lethality during the larval stage. Anti-Misato antibody (122.321) enables researchers to gain valuable insights into the mechanisms of cell division and developmental processes in Drosophila, making this tool essential for studies in developmental biology and genetics.

The preferred Misato antibody is Misato Antibody (E-10): sc-390638.