MIS Antibody (A-9): sc-377140

MIS Antibody (A-9) is a mouse monoclonal IgG1 antibody that detects Mullerian inhibiting substance (MIS) in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-MIS antibody (A-9) plays a crucial role in embryonic development and is primarily produced by Sertoli cells in the testis, where MIS is essential for male sexual differentiation. MIS, along with testosterone, leads to the regression of the Mullerian ducts, which are responsible for female reproductive structures, while promoting the development of the Wolffian ducts, which form male reproductive structures. This regulatory function is vital for preventing the development of female reproductive anatomy in male embryos. Additionally, MIS has been shown to inhibit the growth of tumors derived from tissues of Mullerian duct origin, highlighting MIS′s potential as a therapeutic target in certain cancers. Furthermore, defects in the MIS pathway can lead to persistent Mullerian duct syndrome type I (PMDS-1), a condition characterized by the failure of Mullerian duct regression in otherwise normal males, underscoring MIS′s importance in reproductive health. MIS monoclonal antibody (A-9) is an invaluable tool for researchers studying developmental biology, reproductive health, and related pathologies.

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MIS Antibody (A-9) References:

1. Serum müllerian-inhibiting substance in Down's syndrome pregnancies.  |  Seifer, DB., et al. 2007. Hum Reprod. 22: 1017-20. PMID: 17218369
2. Mullerian inhibiting substance inhibits invasion and migration of epithelial cancer cell lines.  |  Chang, HL., et al. 2011. Gynecol Oncol. 120: 128-34. PMID: 21056908
3. Mullerian inhibiting substance recruits ALK3 to regulate Leydig cell differentiation.  |  Wu, X., et al. 2012. Endocrinology. 153: 4929-37. PMID: 22872577
4. Serum levels of müllerian inhibiting substance in boys from birth to 18 years, as determined by enzyme immunoassay.  |  Baker, ML., et al. 1990. J Clin Endocrinol Metab. 70: 11-5. PMID: 2403569
5. Müllerian inhibiting substance as oocyte meiosis inhibitor.  |  Takahashi, M., et al. 1986. Mol Cell Endocrinol. 47: 225-34. PMID: 2428679
6. Patterns of Müllerian Inhibiting Substance Type II and Candidate Type I Receptors in Epithelial Ovarian Cancer.  |  Basal, E., et al. 2016. Curr Mol Med. 16: 222-31. PMID: 26917267
7. Müllerian inhibiting substance/anti-Müllerian hormone type II receptor protein and mRNA expression in the healthy and cancerous endometria.  |  Kim, SM., et al. 2019. Oncol Lett. 17: 532-538. PMID: 30655798
8. Mullerian inhibiting substance, sex hormone binding globulin and sex hormone levels in stimulant-naïve, first-diagnosed prepubertal boys with attention-deficit/hyperactivity disorder: comparison with matched healthy controls as well as before and after oros-methylpenidate treatment.  |  Gokcen, C., et al. 2019. Int J Psychiatry Clin Pract. 23: 251-257. PMID: 31339400
9. Müllerian-inhibiting substance function during mammalian sexual development.  |  Behringer, RR., et al. 1994. Cell. 79: 415-25. PMID: 7954809
10. Measurements of serum müllerian inhibiting substance in the evaluation of children with nonpalpable gonads.  |  Lee, MM., et al. 1997. N Engl J Med. 336: 1480-6. PMID: 9154766

The preferred MIS antibody is MIS Antibody (B-11): sc-166752.