MHC class II Antibody (15G4): sc-53946
- MHC class II Antibody (15G4) is a mouse monoclonal IgG1 κ, cited in 4 publications, provided at 200 µg/ml
- raised against LPS B cell blasts of H-2M knockout mouse origin
- recommended for detection of MHC class II molecule I-Ab bound to invariant chain (Ii) degradation intermediates p12 and class II-associated invariant chain peptides (CLIP) of mouse origin; not recommended for detection of MHC class II molecule I-Ab bound to human invariant chain degradation intermediates of mouse origin by IP, IF and FCM; not recommended for detection of MHC class II molecule I-Ab bound to human invariant chain degradation intermediates
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MHC class II Antibody (15G4). These reagents are now offered in bundles with MHC class II Antibody (15G4) (see ordering information below).
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SEE ALSO...
MHC class II Antibody (15G4) is a mouse monoclonal IgG1 antibody that detects MHC class II in mouse samples through applications such as immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM). MHC class II molecules play a crucial role in the immune response by presenting processed exogenous antigens to helper T lymphocytes, which are essential for orchestrating adaptive immunity. MHC class II proteins are primarily located on the surface of antigen-presenting cells, including B cells, dendritic cells, and macrophages, where MHC class II facilitates the activation of CD4+ T cells. The ability of MHC class II to bind longer antigenic peptides, typically ranging from 13 to 18 amino acids, is vital for effective immune signaling, as such binding allows for a diverse range of antigens to be presented, thus enhancing the immune system′s ability to recognize and respond to various pathogens. The interaction between MHC class II and T cell receptors is a key event in the immune response, making MHC class II (15G4) antibody essential for understanding immune regulation and potential therapeutic interventions. MHC class II (15G4) antibody serves as an invaluable tool for researchers investigating the complexities of immune responses in mouse models.
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MHC class II Antibody (15G4) References:
- Genetic control of MHC class II expression. | Ting, JP. and Trowsdale, J. 2002. Cell. 109 Suppl: S21-33. PMID: 11983150
- Synaptotagmin II negatively regulates MHC class II presentation by mast cells. | Baram, D., et al. 2002. Mol Immunol. 38: 1347-52. PMID: 12217406
- Studying MHC class II transport in dendritic cells. | Paul, P. and Neefjes, J. 2013. Methods Mol Biol. 960: 489-507. PMID: 23329509
- HLA-DO and Its Role in MHC Class II Antigen Presentation. | Poluektov, YO., et al. 2013. Front Immunol. 4: 260. PMID: 24009612
- High-resolution analysis of the murine MHC class II immunopeptidome. | Sofron, A., et al. 2016. Eur J Immunol. 46: 319-28. PMID: 26495903
- MHC class II complexes sample intermediate states along the peptide exchange pathway. | Wieczorek, M., et al. 2016. Nat Commun. 7: 13224. PMID: 27827392
- Biochemistry of MHC class II molecules. | Giles, RC. and Capra, JD. 1985. Tissue Antigens. 25: 57-68. PMID: 3887644
- Endogenous antigen presentation by MHC class II molecules. | Sant, AJ. 1994. Immunol Res. 13: 253-67. PMID: 7616053
- The MHC class II-associated invariant chain: a molecule with multiple roles in MHC class II biosynthesis and antigen presentation to CD4+ T cells. | Bertolino, P. and Rabourdin-Combe, C. 1996. Crit Rev Immunol. 16: 359-79. PMID: 8954255
- Retroelements in the human MHC class II region. | Andersson, G., et al. 1998. Trends Genet. 14: 109-14. PMID: 9540408
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MHC class II Antibody (15G4) | sc-53946 | 200 µg/ml | $322.00 | |||
MHC class II Antibody (15G4): m-IgG Fc BP-HRP Bundle | sc-539015 | 200 µg Ab; 10 µg BP | $361.00 | |||
MHC class II Antibody (15G4): m-IgG1 BP-HRP Bundle | sc-541208 | 200 µg Ab; 20 µg BP | $361.00 | |||
MHC class II Antibody (15G4) FITC | sc-53946 FITC | 200 µg/ml | $336.00 | |||
MHC class II Antibody (15G4) PE | sc-53946 PE | 200 µg/ml | $349.00 |