MHC class I Antibody (VPM 19): sc-59205

MHC class I Antibody (VPM 19) is a mouse monoclonal IgG1 lambda light chain antibody, engineered to recognize Major Histocompatibility Complex class I (MHC I) proteins, also known as H-2 molecules in sheep and cattle. Anti-MHC class I antibody (VPM 19) is raised against thymocytes of ovine origin, ensuring precise targeting of MHC class I molecules present on lymphocytes isolated from peripheral blood or efferent lymph of both ovine and bovine species. MHC class I proteins undergo critical post-translational modifications, such as N-linked glycosylation, which are essential for proper folding, stability, and surface expression, as well as for effective presentation of endogenous peptides to cytotoxic T lymphocytes. These modifications play a pivotal role in immune recognition and response, making accurate detection of MHC class I molecules crucial for studies in immunology and cellular biology. MHC class I monoclonal antibody (VPM 19) is recommended for use in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and flow cytometry (FCM), providing versatile applications for researchers investigating antigen presentation, immune cell interactions, and related immune mechanisms. Available in both conjugated and unconjugated forms, MHC class I (VPM 19) antibody offers flexibility for various experimental setups, facilitating reliable and reproducible results.

The preferred MHC class I antibody is MHC class I Antibody (W6/32): sc-32235.