MFF Antibody (C-11): sc-398731
- MFF Antibody (C-11) is a mouse monoclonal IgG1 κ, cited in 6 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 91-113 within a cytoplasmic domain of MFF of human origin
- recommended for detection of MFF of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MFF Antibody (C-11) for WB applications. These reagents are now offered in bundles with MFF Antibody (C-11) (see ordering information below).
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MFF Antibody (C-11) is a mouse monoclonal IgG1 antibody that detects MFF (mitochondrial fission factor) in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MFF is a crucial 342 amino acid single-pass type IV membrane protein located in the outer membrane of mitochondria, playing a vital role in mitochondrial and peroxisomal fission, which is essential for maintaining cellular energy homeostasis and regulating apoptosis. The proper functioning of MFF facilitates the dynamic remodeling of mitochondria, allowing cells to adapt to metabolic demands and stress conditions. MFF is expressed abundantly in various tissues, including the stomach, heart, muscle, liver, brain, and kidney, and exists as five alternatively spliced isoforms encoded by a gene located on human chromosome 2q36.3. This chromosome is significant as it is the second largest in the human genome, containing over 1,400 genes and being associated with several genetic diseases. MFF (C-11) antibody is an invaluable tool for researchers studying mitochondrial dynamics and related pathologies, providing insights into the molecular mechanisms underlying various diseases linked to mitochondrial dysfunction.
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MFF Antibody (C-11) References:
- Dynamin-related Protein 1 Oligomerization in Solution Impairs Functional Interactions with Membrane-anchored Mitochondrial Fission Factor. | Clinton, RW., et al. 2016. J Biol Chem. 291: 478-92. PMID: 26578514
- T-cell-restricted intracellular antigen 1 facilitates mitochondrial fragmentation by enhancing the expression of mitochondrial fission factor. | Tak, H., et al. 2017. Cell Death Differ. 24: 49-58. PMID: 27612012
- microRNA-200a-3p enhances mitochondrial elongation by targeting mitochondrial fission factor. | Lee, H., et al. 2017. BMB Rep. 50: 214-219. PMID: 28148392
- Accelerated dentinogenesis by inhibiting the mitochondrial fission factor, dynamin related protein 1. | Matsuishi, YI., et al. 2018. Biochem Biophys Res Commun. 495: 1655-1660. PMID: 29223396
- Mitochondrial fission factor is a novel Myc-dependent regulator of mitochondrial permeability in cancer. | Seo, JH., et al. 2019. EBioMedicine. 48: 353-363. PMID: 31542392
- Mitochondrial fission factor (MFF) is a critical regulator of peroxisome maturation. | Passmore, JB., et al. 2020. Biochim Biophys Acta Mol Cell Res. 1867: 118709. PMID: 32224193
- The mitochondrial fission factor FIS1 promotes stemness of human lung cancer stem cells via mitophagy. | Liu, D., et al. 2021. FEBS Open Bio. 11: 1997-2007. PMID: 34051059
- Non-alcoholic fatty liver disease in mice with hepatocyte-specific deletion of mitochondrial fission factor. | Takeichi, Y., et al. 2021. Diabetologia. 64: 2092-2107. PMID: 34052855
- PEX11β and FIS1 cooperate in peroxisome division independently of mitochondrial fission factor. | Schrader, TA., et al. 2022. J Cell Sci. 135: PMID: 35678336
- Nuclear receptor subfamily 4 group A member 1 promotes myocardial ischemia/reperfusion injury through inducing mitochondrial fission factor-mediated mitochondrial fragmentation and inhibiting FUN14 domain containing 1-depedent mitophagy. | Wang, J., et al. 2024. Int J Biol Sci. 20: 4458-4475. PMID: 39247823
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MFF Antibody (C-11) | sc-398731 | 200 µg/ml | $316.00 | |||
MFF Antibody (C-11): m-IgG Fc BP-HRP Bundle | sc-538513 | 200 µg Ab; 10 µg BP | $354.00 | |||
MFF Antibody (C-11): m-IgGκ BP-HRP Bundle | sc-536139 | 200 µg Ab; 40 µg BP | $354.00 | |||
MFF Antibody (C-11): m-IgG1 BP-HRP Bundle | sc-545742 | 200 µg Ab; 20 µg BP | $354.00 | |||
MFF (C-11) Neutralizing Peptide | sc-398731 P | 100 µg/0.5 ml | $68.00 |