MFF Activators
MFF activators are a class of chemical compounds that enhance the functional activity of the MFF protein through their roles in various biochemical pathways. These activators primarily influence the cAMP-PKA signaling pathway, leading to the enhanced function of MFF. Forskolin, Epinephrine, and Isoproterenol are some key examples of MFF activators that increase cAMP levels, thereby activating PKA, which in turn phosphorylates MFF, enhancing its fission activity. IBMX, Rolipram, Papaverine, Theophylline, and Zardaverine function as phosphodiesterase inhibitors, preventing the degradation of cAMP, resulting in its accumulation, and subsequent PKA activation and MFF phosphorylation.
Furthermore, the MFF activators also include compounds that can induce a superactivation state of PKA under high cAMP conditions, as seen with H-89. Bucladesine, a cAMP analog, directly activates PKA, leading to MFF phosphorylation, while Vinpocetine and Milrinone, as PDE1 and PDE3 inhibitors respectively, augment cAMP levels, thus indirectly enhancing the function of MFF.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is an activator of adenylyl cyclase, which in turn increases the levels of cAMP in cells. Elevated cAMP levels can trigger the activation of Protein Kinase A (PKA), which is known to phosphorylate and activate MFF, leading to enhanced fission activity. | ||||||
(−)-Epinephrine | 51-43-4 | sc-205674 sc-205674A sc-205674B sc-205674C sc-205674D | 1 g 5 g 10 g 100 g 1 kg | $41.00 $104.00 $201.00 $1774.00 $16500.00 | ||
Epinephrine, a catecholamine, stimulates beta-adrenergic receptors, leading to an increase in cAMP levels. This, in turn, activates PKA, which can phosphorylate and activate MFF, enhancing its function. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
Isoproterenol is a beta-adrenergic agonist that can increase intracellular cAMP levels, leading to the activation of PKA. PKA can phosphorylate and activate MFF, thus enhancing its function. | ||||||
IBMX | 28822-58-4 | sc-201188 sc-201188B sc-201188A | 200 mg 500 mg 1 g | $260.00 $350.00 $500.00 | 34 | |
IBMX is a non-selective inhibitor of phosphodiesterases, enzymes that degrade cAMP. By inhibiting these enzymes, IBMX can indirectly increase cAMP levels, leading to the activation of PKA, which then phosphorylates and activates MFF. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram is a selective inhibitor of phosphodiesterase 4 (PDE4). By inhibiting PDE4, Rolipram can increase cAMP levels, leading to PKA activation, which then phosphorylates and activates MFF, enhancing mitochondrial fission. | ||||||
H-89 dihydrochloride | 130964-39-5 | sc-3537 sc-3537A | 1 mg 10 mg | $94.00 $186.00 | 71 | |
H-89 is a potent PKA inhibitor. While it primarily works by inhibiting PKA, under conditions of high cAMP, it can lead to superactivation of PKA, which then activates MFF. | ||||||
Papaverine | 58-74-2 | sc-279951 sc-279951A sc-279951B | 10 mg 50 mg 100 mg | $153.00 $265.00 $459.00 | ||
Papaverine is a non-selective phosphodiesterase inhibitor. It can increase cAMP levels, leading to the activation of PKA, which can then phosphorylate and activate MFF, enhancing its functional activity. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
Bucladesine is a cAMP analog that can directly activate PKA. The activated PKA can then phosphorylate and activate MFF, enhancing its function. | ||||||
Theophylline | 58-55-9 | sc-202835 sc-202835A sc-202835B | 5 g 25 g 100 g | $20.00 $32.00 $85.00 | 6 | |
Theophylline is a non-selective phosphodiesterase inhibitor. It can increase cAMP levels, leading to the activation of PKA, which can then phosphorylate and activate MFF, enhancing its functional activity. | ||||||
Zardaverine | 101975-10-4 | sc-201208 sc-201208A | 5 mg 25 mg | $88.00 $379.00 | 1 | |
Zardaverine is a PDE3 and PDE4 inhibitor. By inhibiting these enzymes, it can increase cAMP levels, leading to activation of PKA, which can then phosphorylate and activate MFF. | ||||||