MEMO1 Antibody (AT1E9): sc-517412

MEMO1 Antibody (AT1E9) is a mouse monoclonal IgG1 kappa light chain antibody that detects MEMO1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). anti-MEMO1 antibody (AT1E9) is available as a non-conjugated format. MEMO1 protein, also known as mediator of cell motility 1, C2orf4, or NS5ATP7, consists of 297 amino acids and plays a crucial role in regulating cell migration by modulating extracellular chemotactic signals directed at the microtubule cytoskeleton. This function is particularly important in the context of tumorigenesis, as MEMO1 is implicated in mediating Neu signaling, which is essential for the migration of breast carcinoma cells. The gene encoding MEMO1 is located on human chromosome 2, a region that contains over 1,400 genes and accounts for nearly 8% of the human genome. Notably, chromosome 2 is also associated with various genetic disorders, including harlequin ichthyosis, linked to mutations in the ABCA12 gene, and lipid metabolic disorders such as sitosterolemia, which are caused by defects in the ABCG5 and ABCG8 genes. The ability of MEMO1 to influence cell motility underscores its significance in both normal physiological processes and pathological conditions, making MEMO1 (AT1E9) antibody a valuable tool for researchers studying cell migration and cancer biology.

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MEMO1 Antibody (AT1E9) References:

1. Frequency and genetic basis of MHC, beta-2-microglobulin and MEMO-1 loss of heterozygosity in sporadic breast cancer.  |  McEvoy, CR., et al. 2002. Tissue Antigens. 60: 235-43. PMID: 12445306
2. Evidence for whole chromosome 6 loss and duplication of the remaining chromosome in acute lymphoblastic leukemia.  |  McEvoy, CR., et al. 2003. Genes Chromosomes Cancer. 37: 321-5. PMID: 12759931
3. Memo mediates ErbB2-driven cell motility.  |  Marone, R., et al. 2004. Nat Cell Biol. 6: 515-22. PMID: 15156151
4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4.  |  Hillier, LW., et al. 2005. Nature. 434: 724-31. PMID: 15815621
5. Memo is homologous to nonheme iron dioxygenases and binds an ErbB2-derived phosphopeptide in its vestigial active site.  |  Qiu, C., et al. 2008. J Biol Chem. 283: 2734-40. PMID: 18045866
6. Memo1-Mediated Tiling of Radial Glial Cells Facilitates Cerebral Cortical Development.  |  Nakagawa, N., et al. 2019. Neuron. 103: 836-852.e5. PMID: 31277925
7. Finding MEMO-Emerging Evidence for MEMO1's Function in Development and Disease.  |  Schotanus, MD. and Van Otterloo, E. 2020. Genes (Basel). 11: PMID: 33172038
8. Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro.  |  Zhang, X., et al. 2022. Proc Natl Acad Sci U S A. 119: e2206905119. PMID: 36067318
9. Copper metabolism in cell death and autophagy.  |  Xue, Q., et al. 2023. Autophagy. 19: 2175-2195. PMID: 37055935
10. Memo1 reduces copper-mediated reactive oxygen species in breast cancer cells.  |  Zhang, X., et al. 2023. J Inorg Biochem. 247: 112335. PMID: 37487298
11. MEMO1 binds iron and modulates iron homeostasis in cancer cells.  |  Dolgova, N., et al. 2024. Elife. 13: PMID: 38640016
12. Lack of class I HLA expression in neuroblastoma is associated with high N-myc expression and hypomethylation due to loss of the MEMO-1 locus.  |  Cheng, NC., et al. 1996. Oncogene. 13: 1737-44. PMID: 8895520

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MEMO1 Antibody (AT1E9) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-MEMO1 Antibody (AT1E9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MEMO1 Antibody (AT1E9) Specifications

Alternate Product Name: MEMO1

Product Clone Name: AT1E9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-297

Epitope Target: MEMO1

Epitope Species: human

Product Reactivity/Detection: MEMO1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide, 0.1% gelatin and < 1% glycerol

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for MEMO1 Antibody (AT1E9): N/A