MDMX Antibody (A-11): sc-374147
- MDMX Antibody (A-11) is a mouse monoclonal IgG2b κ, cited in 4 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 163-199 an internal region of MDMX of human origin
- recommended for detection of MDMX of mouse, rat and human origin by WB, IP, IF and ELISA
- See MDMX (G-10): sc-74467 for MDMX antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MDMX Antibody (A-11) for WB applications. These reagents are now offered in bundles with MDMX Antibody (A-11) (see ordering information below).
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MDMX Antibody (A-11) is a mouse monoclonal IgG2b antibody that detects MDMX in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MDMX plays a crucial role in regulating the stability of the p53 protein, a key tumor suppressor involved in cell cycle control and apoptosis. By inhibiting MDM2-mediated degradation of p53, MDMX ensures that p53 levels are maintained, which is vital for the cellular response to stress and DNA damage. The interaction between MDMX and p53 is particularly important in the context of cancer, as the amplification of the MDMX gene (also known as MDM4) is frequently observed in malignant gliomas, contributing to tumor progression by allowing cancer cells to evade apoptosis. Furthermore, MDMX′s ability to bind and stabilize p73, another member of the p53 family, highlights its multifaceted role in regulating cell survival and death pathways. Anti-MDMX antibody (A-11) is an essential tool for researchers studying the intricate balance of these proteins in various biological processes and disease states.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
MDMX Antibody (A-11) References:
- Mdmx promotes genomic instability independent of p53 and Mdm2. | Carrillo, AM., et al. 2015. Oncogene. 34: 846-56. PMID: 24608433
- Secondary interaction between MDMX and p53 core domain inhibits p53 DNA binding. | Wei, X., et al. 2016. Proc Natl Acad Sci U S A. 113: E2558-63. PMID: 27114532
- p53 binds the mdmx mRNA and controls its translation. | Tournillon, AS., et al. 2017. Oncogene. 36: 723-730. PMID: 27375027
- MDMX Recruits UbcH5c to Facilitate MDM2 E3 Ligase Activity and Subsequent p53 Degradation In Vivo. | Yang, J., et al. 2021. Cancer Res. 81: 898-909. PMID: 33277368
- MDMX is essential for the regulation of p53 protein levels in the absence of a functional MDM2 C-terminal tail. | Sanford, JD., et al. 2021. BMC Mol Cell Biol. 22: 46. PMID: 34551723
- The ion channel TRPM7 regulates zinc-depletion-induced MDMX degradation. | Wang, H., et al. 2021. J Biol Chem. 297: 101292. PMID: 34627839
- Leveraging the multivalent p53 peptide-MdmX interaction to guide the improvement of small molecule inhibitors. | Cheng, X., et al. 2022. Nat Commun. 13: 1087. PMID: 35228542
- Molecular investigation of the dual inhibition mechanism for targeted P53 regulator MDM2/MDMX inhibitors. | Zhao, X., et al. 2022. Phys Chem Chem Phys. 24: 16799-16815. PMID: 35775962
- Milk as an extender for semen: a review. | Kakar, SS. and Ganguli, NC. 1978. Indian J Anim Sci. 48: 777-90. PMID: 374147
- Molecular mechanism of CCDC106 regulating the p53-Mdm2/MdmX signaling axis. | Zhou, T., et al. 2023. Sci Rep. 13: 21892. PMID: 38081879
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MDMX Antibody (A-11) | sc-374147 | 200 µg/ml | $322.00 | |||
MDMX Antibody (A-11): m-IgGκ BP-HRP Bundle | sc-535397 | 200 µg Ab; 40 µg BP | $361.00 | |||
MDMX Antibody (A-11): m-IgG2b BP-HRP Bundle | sc-549407 | 200 µg Ab; 10 µg BP | $361.00 | |||
MDMX (A-11) Neutralizing Peptide | sc-374147 P | 100 µg/0.5 ml | $69.00 |