MDHC Antibody (A-4): sc-166880

MDHC Antibody (A-4) is a mouse monoclonal IgG2b antibody that detects malate dehydrogenase (MDHC) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MDHC is a crucial NAD-dependent enzyme that plays a significant role in glycometabolism by catalyzing the conversion of L-malate and NAD into oxaloacetate and NADH, which is essential for energy production in aerobic conditions. This enzyme is predominantly found in the cytosol of cells in the brain, heart, and skeletal muscle, where MDHC supports vital processes such as muscle contraction, neuronal signal transmission, and cellular respiration. The structural integrity of MDHC, functioning as a homodimer, is vital for enzymatic activity and is highly conserved across various species, including plants and bacteria. Additionally, MDHC serves as a regulatory subunit of the nucleic acid-conducting channel, highlighting MDHC′s importance in cellular functions. MDHC activity is modulated by hormones such as the sesquiterpenoid juvenile hormone and the steroid hormone ecdysone, which underscores MDHC′s role in metabolic regulation and potential implications in developmental biology and energy homeostasis.

The preferred MDHC antibody is MDHC Antibody (H-6): sc-166879.