MBLAC2 Antibody (A-4): sc-398284
- MBLAC2 Antibody (A-4) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 84-103 within an internal region of MBLAC2 of human origin
- recommended for detection of MBLAC2 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and bovine and porcine
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for MBLAC2 Antibody (A-4) for WB applications. These reagents are now offered in bundles with MBLAC2 Antibody (A-4) (see ordering information below).
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MBLAC2 Antibody (A-4) is a mouse monoclonal IgG1 antibody that detects MBLAC2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MBLAC2, also known as metallo-beta-lactamase domain-containing protein 2, is a 279 amino acid protein that plays a crucial role in cellular detoxification processes by hydrolyzing toxic metabolites, thereby protecting cells from oxidative stress. MBLAC2 is part of the glyoxalase II family and the metallo-beta-lactamase superfamily, and binds two zinc ions, which are essential for enzymatic activity. MBLAC2 is encoded by a gene located on human chromosome 5q14.3, a region that comprises nearly 6% of the human genome and is associated with various genetic disorders, including Cockayne syndrome and familial adenomatous polyposis. MBLAC2′s presence in cellular compartments underscores its importance in maintaining cellular homeostasis and preventing damage from harmful compounds, making anti-MBLAC2 antibody (A-4) an invaluable tool for researchers studying implications in health and disease.
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MBLAC2 Antibody (A-4) References:
- Metallo-β-lactamase Domain-Containing Protein 1 (MBLAC1) Is a Specific, High-Affinity Target for the Glutamate Transporter Inducer Ceftriaxone. | Retzlaff, CL., et al. 2017. ACS Chem Neurosci. 8: 2132-2138. PMID: 28783953
- Diversity and complexity of flavodiiron NO/O2 reductases. | Folgosa, F., et al. 2018. FEMS Microbiol Lett. 365: PMID: 29240952
- ADGRV1 is implicated in myoclonic epilepsy. | Myers, KA., et al. 2018. Epilepsia. 59: 381-388. PMID: 29266188
- Human metallo-β-lactamase enzymes degrade penicillin. | Diene, SM., et al. 2019. Sci Rep. 9: 12173. PMID: 31434986
- Metallo-β-lactamase domain-containing protein 2 is S-palmitoylated and exhibits acyl-CoA hydrolase activity. | Malgapo, MIP., et al. 2021. J Biol Chem. 296: 100106. PMID: 33219126
- Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. | Lechner, S., et al. 2022. Nat Chem Biol. 18: 812-820. PMID: 35484434
- Chemical Proteomics Reveals MBLAC2 as a Major Off-Target of HDAC Inhibitors. | . 2022. Cancer Discov. 12: 1607. PMID: 35554509
- Author Correction: Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target. | Lechner, S., et al. 2022. Nat Chem Biol. 18: 913. PMID: 35840679
- In-Cell Testing of Zinc-Dependent Histone Deacetylase Inhibitors in the Presence of Class-Selective Fluorogenic Substrates: Potential and Limitations of the Method. | Kleymenova, A., et al. 2024. Biomedicines. 12: PMID: 38927410
- Proteomics analysis of periplaque and chronic inactive multiple sclerosis lesions. | Wilkins, JM., et al. 2024. Front Mol Neurosci. 17: 1448215. PMID: 39234409
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MBLAC2 Antibody (A-4) | sc-398284 | 200 µg/ml | $322.00 | |||
MBLAC2 Antibody (A-4): m-IgG Fc BP-HRP Bundle | sc-538411 | 200 µg Ab; 10 µg BP | $361.00 | |||
MBLAC2 Antibody (A-4): m-IgGκ BP-HRP Bundle | sc-536020 | 200 µg Ab; 40 µg BP | $361.00 | |||
MBLAC2 Antibody (A-4): m-IgG1 BP-HRP Bundle | sc-545691 | 200 µg Ab; 20 µg BP | $361.00 | |||
MBLAC2 (A-4) Neutralizing Peptide | sc-398284 P | 100 µg/0.5 ml | $69.00 |