MBLAC2 Antibody (E-7): sc-398153

MBLAC2 Antibody (E-7) is a mouse monoclonal IgG2a kappa light chain antibody that detects MBLAC2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MBLAC2 (E-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MBLAC2, also known as metallo-beta-lactamase domain-containing protein 2, consists of 279 amino acids and is a member of the glyoxalase II family and the metallo-beta-lactamase superfamily. MBLAC2 plays a crucial role in cellular detoxification processes by hydrolyzing toxic metabolites, which is essential for maintaining cellular health and preventing damage from reactive compounds. MBLAC2 binds two zinc ions, which are vital for enzymatic activity, and is encoded by a gene located on human chromosome 5q14.3. This chromosome is significant not only for its size, comprising nearly 6% of the human genome, but also for its association with various genetic disorders, including Cockayne syndrome and familial adenomatous polyposis. MBLAC2′s ability to interact with specific substrates and involvement in critical metabolic pathways underscore its importance in both normal physiology and disease states, making anti-MBLAC2 antibody (E-7) a valuable tool for researchers studying these processes.

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MBLAC2 Antibody (E-7) References:

1. Duodenal adenomatosis in familial adenomatous polyposis coli. A review of the literature and results from the Heidelberg Polyposis Register.  |  Kadmon, M., et al. 2001. Int J Colorectal Dis. 16: 63-75. PMID: 11355321
2. The gene for Treacher Collins syndrome maps to the long arm of chromosome 5.  |  Dixon, MJ., et al. 1991. Am J Hum Genet. 49: 17-22. PMID: 1676560
3. Cockayne syndrome exhibits dysregulation of p21 and other gene products that may be independent of transcription-coupled repair.  |  Cleaver, JE., et al. 2007. Neuroscience. 145: 1300-8. PMID: 17055654
4. A new genomic mechanism leading to cri-du-chat syndrome.  |  South, ST., et al. 2006. Am J Med Genet A. 140: 2714-20. PMID: 17103439
5. Redefining monosomy 5 by molecular cytogenetics in 23 patients with MDS/AML.  |  Herry, A., et al. 2007. Eur J Haematol. 78: 457-67. PMID: 17391336
6. Somatic APC mosaicism: a frequent cause of familial adenomatous polyposis (FAP).  |  Aretz, S., et al. 2007. Hum Mutat. 28: 985-92. PMID: 17486639
7. Telomerase reverse transcriptase haploinsufficiency and telomere length in individuals with 5p- syndrome.  |  Du, HY., et al. 2007. Aging Cell. 6: 689-97. PMID: 17875000
8. Molecular mechanisms of skin aging: state of the art.  |  Makrantonaki, E. and Zouboulis, CC. 2007. Ann N Y Acad Sci. 1119: 40-50. PMID: 18056953
9. Metallo-β-lactamase domain-containing protein 2 is S-palmitoylated and exhibits acyl-CoA hydrolase activity.  |  Malgapo, MIP., et al. 2021. J Biol Chem. 296: 100106. PMID: 33219126
10. Target deconvolution of HDAC pharmacopoeia reveals MBLAC2 as common off-target.  |  Lechner, S., et al. 2022. Nat Chem Biol. 18: 812-820. PMID: 35484434
11. Chemical Proteomics Reveals MBLAC2 as a Major Off-Target of HDAC Inhibitors.  |  . 2022. Cancer Discov. 12: 1607. PMID: 35554509
12. A physical map of 15 loci on human chromosome 5q23-q33 by two-color fluorescence in situ hybridization.  |  Saltman, DL., et al. 1993. Genomics. 16: 726-32. PMID: 8325647

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MBLAC2 Antibody (E-7) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-MBLAC2 Antibody (E-7) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MBLAC2 Antibody (E-7) Specifications

Alternate Product Name: MBLAC2

Product Clone Name: E-7

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 82-107

Epitope Target: MBLAC2

Epitope Species: human

Product Reactivity/Detection: MBLAC2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: bovine and porcine

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for MBLAC2 Antibody (E-7): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin