MAT IIβ Antibody (G-6): sc-514068

MAT IIβ Antibody (G-6) is a mouse monoclonal IgG2a antibody that detects MAT IIβ in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). MAT IIβ, also known as methionine adenosyltransferase II, beta, TGR, MAT-II, or SDR23E1, is a 334 amino acid protein that plays a crucial role in amino acid biosynthesis and is widely expressed in various tissues, particularly in the liver. MAT IIβ exists as a heterotetramer alongside two MAT IIα subunits, functioning primarily as a non-catalytic regulatory protein that modulates MAT IIα activity by altering kinetic properties, which enhances susceptibility to inhibition. MAT IIα regulation by MAT IIβ influences methionine catabolism and, consequently, the synthesis of S-adenosylmethionine (AdoMet), a critical methyl donor involved in numerous biological processes, including DNA methylation and gene expression regulation. MAT IIβ is expressed in hepatoma cells and contributes to cell proliferation by potentially increasing DNA synthesis rate, highlighting MAT IIβ importance in cellular growth and metabolism. Multiple isoforms of MAT IIβ arise from alternative splicing events, which may further diversify functional roles in different cellular contexts.

The preferred MAT IIβ antibody is MAT IIβ Antibody (A-3): sc-390586.