MAS1 Antibody (G-1): sc-390453

MAS1 Antibody (G-1) is a mouse monoclonal IgG1 kappa light chain antibody that detects MAS1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). MAS1 (G-1) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. MAS1 protein, a proto-oncogene, functions as a G protein-coupled receptor located on the plasma membrane, playing a crucial role in cardiovascular physiology. MAS1 acts as an antagonist to the Angiotensin II type 1 (AT1) receptor, thereby inhibiting the effects of Angiotensin II, which is vital for regulating blood pressure and fluid balance. MAS1 localization to cardiomyocytes in the heart underscores its importance in maintaining proper cardiac function; studies have shown that mice lacking MAS1 exhibit reduced systolic tension and heart rate, indicating that dysfunctional MAS1 can lead to impaired cardiac structure and function. MAS1 significance in cardiovascular health and disease makes anti-MAS1 antibody (G-1) an essential tool for researchers studying its role in various physiological and pathological processes.

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MAS1 Antibody (G-1) References:

1. Imprinting of the murine MAS protooncogene is restricted to its antisense RNA.  |  Alenina, N., et al. 2002. Biochem Biophys Res Commun. 290: 1072-8. PMID: 11798184
2. G-protein-coupled receptor Mas is a physiological antagonist of the angiotensin II type 1 receptor.  |  Kostenis, E., et al. 2005. Circulation. 111: 1806-13. PMID: 15809376
3. Angiotensin-(1-7) inhibits growth of cardiac myocytes through activation of the mas receptor.  |  Tallant, EA., et al. 2005. Am J Physiol Heart Circ Physiol. 289: H1560-6. PMID: 15951342
4. Short-term angiotensin(1-7) receptor MAS stimulation improves endothelial function in normotensive rats.  |  Faria-Silva, R., et al. 2005. Hypertension. 46: 948-52. PMID: 16087780
5. Evidence for a functional interaction of the angiotensin-(1-7) receptor Mas with AT1 and AT2 receptors in the mouse heart.  |  Castro, CH., et al. 2005. Hypertension. 46: 937-42. PMID: 16157793
6. Impairment of in vitro and in vivo heart function in angiotensin-(1-7) receptor MAS knockout mice.  |  Santos, RA., et al. 2006. Hypertension. 47: 996-1002. PMID: 16567589
7. Up-regulation of the angiotensin II type 1 receptor by the MAS proto-oncogene is due to constitutive activation of Gq/G11 by MAS.  |  Canals, M., et al. 2006. J Biol Chem. 281: 16757-67. PMID: 16611642
8. Functional rescue of a defective angiotensin II AT1 receptor mutant by the Mas protooncogene.  |  Santos, EL., et al. 2007. Regul Pept. 141: 159-67. PMID: 17320985
9. Involvement of ACE2/Ang-(1-7)/MAS1 Axis in the Regulation of Ovarian Function in Mammals.  |  Domińska, K. 2020. Int J Mol Sci. 21: PMID: 32604999
10. ACE2/Ang-(1-7)/Mas1 axis and the vascular system: vasoprotection to COVID-19-associated vascular disease.  |  Kuriakose, J., et al. 2021. Clin Sci (Lond). 135: 387-407. PMID: 33511992
11. G protein-coupled receptor MAS1 induces an inhibitory effect on myocardial infarction-induced myocardial injury.  |  Zhou, G., et al. 2022. Int J Biol Macromol. 207: 72-80. PMID: 35247425
12. Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains.  |  Young, D., et al. 1986. Cell. 45: 711-9. PMID: 3708691

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-MAS1 Antibody (G-1) has 20 citations in a variety of scientific publications.

Primary antibodies like Anti-MAS1 Antibody (G-1) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

MAS1 Antibody (G-1) Specifications

Alternate Product Name: MAS

Product Clone Name: G-1

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-117

Epitope Target: MAS1

Epitope Species: human

Product Reactivity/Detection: MAS1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 20 citations in various scientific publications

Available Conjugates/Forms for MAS1 Antibody (G-1): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin