MAS1 Inhibitors
MAS1 inhibitors belong to a specific chemical class that plays a crucial role in modulating the renin-angiotensin system (RAS), which is responsible for regulating blood pressure and maintaining fluid and electrolyte balance in the body. These inhibitors target the MAS1 receptor, a G-protein-coupled receptor found predominantly in the cardiovascular system and various other tissues, such as the brain, kidney, and gastrointestinal tract. The MAS1 receptor is a part of the renin-angiotensin system and is involved in counterbalancing the effects of the angiotensin II type 1 receptor (AT1 receptor). When activated, the MAS1 receptor exerts vasodilatory, anti-inflammatory, and antiproliferative effects, which are in contrast to the vasoconstrictive and pro-inflammatory effects associated with the activation of the AT1 receptor.
Chemically, MAS1 inhibitors are designed to selectively bind to the MAS1 receptor, preventing its activation by its natural ligand, angiotensin-(1-7). By inhibiting the MAS1 receptor, these compounds modulate the overall activity of the renin-angiotensin system, leading to altered blood pressure regulation and other physiological effects. It focuses on their role within the renin-angiotensin system and their molecular interactions with the MAS1 receptor.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Captopril | 62571-86-2 | sc-200566 sc-200566A | 1 g 5 g | $48.00 $89.00 | 21 | |
Captopril inhibits the conversion of angiotensin I to angiotensin II, which may increase levels of angiotensin-(1-7) and potentially lead to MAS1 downregulation. | ||||||
Dexamethasone | 50-02-2 | sc-29059 sc-29059B sc-29059A | 100 mg 1 g 5 g | $76.00 $82.00 $367.00 | 36 | |
Dexamethasone can regulate gene expression broadly, potentially affecting MAS1 expression. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This agent can alter gene expression patterns, potentially affecting MAS1. | ||||||
Imatinib | 152459-95-5 | sc-267106 sc-267106A sc-267106B | 10 mg 100 mg 1 g | $25.00 $117.00 $209.00 | 27 | |
By influencing intracellular signaling pathways, Imatinib might alter MAS1 activity or expression. | ||||||
Pertussis Toxin (islet-activating protein) | 70323-44-3 | sc-200837 | 50 µg | $442.00 | 3 | |
This compound directly inhibits G protein activity, potentially affecting MAS1 signaling. | ||||||
Nifedipine | 21829-25-4 | sc-3589 sc-3589A | 1 g 5 g | $58.00 $170.00 | 15 | |
By affecting calcium influx, Nifedipine might indirectly influence MAS1 activity. | ||||||
L-NG-Nitroarginine Methyl Ester (L-NAME) | 51298-62-5 | sc-200333 sc-200333A sc-200333B | 1 g 5 g 25 g | $47.00 $105.00 $322.00 | 45 | |
L-NAME might alter nitric oxide levels, potentially affecting MAS1-mediated vasodilatory responses. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $45.00 | 5 | |
By modulating oxidative stress, L-Ascorbic acid, free acidmight indirectly influence MAS1 expression or activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin's antioxidant properties might indirectly affect MAS1 signaling. | ||||||