Pertussis Toxin (islet-activating protein) CAS: 70323-44-3
A toxin that blocks reduction of adenylate cyclase activity.

Pertussis Toxin (islet-activating protein) (CAS 70323-44-3)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 122ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
1
4
0
3
0
2
0
1
0
Sinónimo: PTX;Holotoxin
Solicitud: A toxin that blocks reduction of adenylate cyclase activity
Número de CAS: 70323-44-3
Pureza: >99%
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* En el Certificado de Análisis específico de lote, puede encontrar información específica (como el contenido en agua).
Envíe una reseña para este producto y reciba 15 créditos Cruz

Pertussis Toxin (islet-activating protein), a toxin originally isolated from Bordetella pertussis, has been shown to catalyze ADP-ribosylation of a protein in membrane preparation from rat C6 glioma cells. In addition, exposure of Chinese hamster ovary cells in culture to this compound has resulted in a clustered growth pattern response. Other experiments have shown Pertussis Toxin to block the ability of inhibitory hormones to reduce adenylate cyclase activity and enhance the ability of stimulatory hormones to activate the enzyme. Mechanistic studies have shown this toxin to consist of subunit A (active) promoter, which disrupts transmembrane signaling by ADP-ribosylating eukaryotic G-proteins, and B (binding) oligomer which helps the toxin bind to cells in vivo.


References

1. Tamura, M., et al. 1982. Biochemistry. 21: 5516-5522. PMID: 6293544
2. Hewlett, E.L., et al. 1983. Infect. Immun. 40: 1198-1203. PMID: 6682833
3. Bokoch, G.M., et al. 1983. J. Biol. Chem. 258: 2072-2075. PMID: 6296122
4. Kaslow, H.R., et al. 1987. Biochemistry. 26: 123-127. PMID: 3030399
5. Kaslow, H.R. and Burns, D.L. 1992. FASEB J. 6: 2684-2690. PMID: 1612292

Estado de Materia :
Solid
Forma Derivada :
Bordetella pertussis
Solubilidad :
Soluble in water (Miscible).
ALMACENAMIENTO :
Store at 4° C
Para Uso Exclusivo en Investigación. No está diseñado para uso en diagnosis o terapia.
WGK Alemania :
3
RTECS :
XW5883750
Número MDL :
MFCD00131841

Descargar SDS (MSDS)

CERTIFICADO DE ANÁLISIS

Necesita Adobe Acrobat Reader para ver de forma fiable,
imprimir y comentar el documento de PDF

Pertussis Toxin (islet-activating protein)  Menciones del Producto

Ver como otros han utilizado Pertussis Toxin (islet-activating protein). Haga click en la entrada de PubMed .

Citaciones 1 a 1 de un total de 1

PMID: # 3158374  Fujita, N. et al. 1985. Brain Res. 333: 231-236.

Citaciones 1 a 1 de un total de 1
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 111ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 11ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

Santa Cruz Biotechnology, Inc. es un líder mundial en el desarrollo de productos para el mercado de la investigación biomédica. Llámenos gratis al 00 800 4573 8000.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. All Rights Reserved."Santa Cruz Biotechnology", y el logo de Santa Cruz Biotechnology, Inc., "Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", el logo de San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", y "EZ Touch" son marcas registradas de Santa Cruz Biotechnology, Inc. Todas las marcas registradas son propiedad de su respectivo dueño.