MAN2C1 Antibody (G-8): sc-271088
- MAN2C1 Antibody (G-8) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- specific for an epitope mapping between amino acids 891-924 within an internal region of MAN2C1 of human origin
- recommended for detection of MAN2C1 of mouse, rat and human origin by WB, IP, IF and ELISA
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for MAN2C1 Antibody (G-8) for WB applications. These reagents are now offered in bundles with MAN2C1 Antibody (G-8) (see ordering information below).
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MAN2C1 Antibody (G-8) is a mouse monoclonal IgG1 antibody that detects MAN2C1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAN2C1, also known as α-mannosidase 2C1, plays a crucial role in the degradation of misfolded glycoproteins by cleaving α 1,2-linked, α 1,3-linked, and α 1,6-linked mannose residues, which is essential for maintaining cellular homeostasis and preventing the accumulation of improperly folded proteins. MAN2C1 is primarily located in the cytosol, where MAN2C1 interacts with free oligosaccharides released during the degradation process, facilitating their catabolism. MAN2C1 activity is stimulated by cobalt, and MAN2C1 inhibition by compounds such as swainsonine and 1,4-dideoxy-1,4-imino-d-mannitol can lead to significant cellular changes, including enhanced adhesion of Jurkat T cells and cytoskeletal rearrangements. Anti-MAN2C1 antibody (G-8) is an invaluable tool for researchers studying glycoprotein metabolism and the cellular responses to glycosylation defects.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
MAN2C1 Antibody (G-8) | sc-271088 | 200 µg/ml | $316.00 | |||
MAN2C1 Antibody (G-8): m-IgG Fc BP-HRP Bundle | sc-540198 | 200 µg Ab; 10 µg BP | $354.00 | |||
MAN2C1 Antibody (G-8): m-IgG1 BP-HRP Bundle | sc-541965 | 200 µg Ab; 20 µg BP | $354.00 | |||
MAN2C1 (G-8) Neutralizing Peptide | sc-271088 P | 100 µg/0.5 ml | $68.00 |