MAGE-D4/MAGE-D4B Antibody (F-9): sc-393058

MAGE-D4/MAGE-D4B Antibody (F-9) is a mouse monoclonal IgG1 antibody that detects MAGE-D4/MAGE-D4B in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). MAGE-D4 and MAGE-D4B are 741 amino acid proteins encoded by the human genes MAGED4 and MAGED4B, respectively, and are part of the MAGE family, which is known for directing the expression of tumor antigens recognized by autologous cytolytic T lymphocytes in human melanomas. MAGE-D4 and MAGE-D4B are glioma-specific members of the MAGE family, with both isoforms uniquely expressed in glioma cells among cancer types, while normal tissue expression is limited to the brain and ovary. Expression of MAGE-D4 and MAGE-D4B in malignant tumors, particularly gliomas, underscores their potential role in tumor biology, although expression levels are not considered prognostic indicators. Anti-MAGE-D4/MAGE-D4B antibody (F-9) provides a valuable tool for researchers investigating these proteins in cancer, particularly in glioma, where understanding their function could lead to insights into tumor immunology and potential therapeutic strategies.

The preferred MAGE-D4/MAGE-D4B antibody is MAGE-D4/MAGE-D4B Antibody (G-12): sc-393059.