MAGE Inhibitors
MAGE inhibitors belong to a distinct chemical class renowned for their specific interaction with melanoma-associated antigen (MAGE) proteins. MAGE proteins, notably expressed in various cancers, particularly melanoma, are pivotal players in tumorigenesis and tumor progression. Inhibitors targeting these proteins aim to impede their function and disrupt the intricate cellular processes they participate in. MAGE inhibitors are characterized by their unique molecular structures designed to selectively bind to MAGE proteins, thereby modulating their activity and interrupting downstream signaling pathways associated with cancer development.
MAGE inhibitors underscores the dynamic nature of their interactions with MAGE proteins. These inhibitors often possess intricate arrangements of functional groups, enabling them to form specific and stable complexes with the target proteins. This selectivity is crucial for minimizing off-target effects. Additionally, the development of novel MAGE inhibitors involves a deep understanding of the structural biology of MAGE proteins, guiding the rational design of compounds with optimal binding affinities. As research in this field progresses, elucidating the nuanced mechanisms by which MAGE inhibitors interfere with cancer-associated processes is pivotal for refining their design and enhancing their efficacy as potential tools for modulating oncogenic pathways influenced by MAGE proteins.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Taxol | 33069-62-4 | sc-201439D sc-201439 sc-201439A sc-201439E sc-201439B sc-201439C | 1 mg 5 mg 25 mg 100 mg 250 mg 1 g | $40.00 $73.00 $217.00 $242.00 $724.00 $1196.00 | 39 | |
Taxol (Paclitaxel) stabilizes microtubules and consequently disrupts cell division, impacting MAGE proteins associated with cell cycle regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin inhibits mTOR pathway, a pathway that MAGE proteins can be involved in, thereby affecting their function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor. Since PI3K/Akt pathway can influence MAGE proteins, this compound can indirectly affect MAGE function. | ||||||
Nutlin-3 | 548472-68-0 | sc-45061 sc-45061A sc-45061B | 1 mg 5 mg 25 mg | $56.00 $212.00 $764.00 | 24 | |
Nutlin-3 activates p53 pathway, thereby influencing MAGE proteins associated with apoptosis. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $226.00 $846.00 | 1 | |
JQ1 inhibits BRD4, a bromodomain protein that may interact with MAGE proteins, influencing their function. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad spectrum kinase inhibitor, which can indirectly affect MAGE function. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 inhibits the proteasome, which can influence MAGE proteins involved in protein degradation. | ||||||
AZD5363 | 1143532-39-1 | sc-503190 | 5 mg | $309.00 | ||
AZD5363 inhibits Akt, a kinase involved in pathways that MAGE proteins can influence. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $182.00 $693.00 | 88 | |
Y-27632 inhibits ROCK pathway, which can influence MAGE proteins. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 inhibits JNK pathway, which can influence MAGE proteins. | ||||||