LYSMD1 Antibody (F-8): sc-515348

LYSMD1 Antibody (F-8) is a mouse monoclonal IgG1 antibody that detects LYSMD1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LYSMD1, also known as SB145, is a 227 amino acid protein characterized by a single LysM repeat and exists in two alternatively spliced isoforms, which may play distinct roles in cellular processes. LYSMD1 is primarily located in the cytoplasm, where LYSMD1 is believed to be involved in the recognition and binding of peptidoglycan, a crucial component of bacterial cell walls. LYSMD1′s ability to interact with peptidoglycan suggests a role in the immune response, particularly in the detection and response to bacterial infections. Furthermore, the gene encoding LYSMD1 is situated on human chromosome 1, a region associated with numerous diseases, including various cancers and genetic disorders. LYSMD1′s presence in the cytoplasm underscores LYSMD1′s potential importance in cellular signaling pathways and immune surveillance, making anti-LYSMD1 antibody (F-8) a valuable tool for researchers studying immune responses and related pathologies.

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LYSMD1 Antibody (F-8) References:

1. HIF-1α is a negative regulator of plasmacytoid DC development in vitro and in vivo.  |  Weigert, A., et al. 2012. Blood. 120: 3001-6. PMID: 22936665
2. Peptidoglycan Isolation and Binding Studies with LysM-Type Pattern Recognition Receptors.  |  Bertsche, U. and Gust, AA. 2017. Methods Mol Biol. 1578: 1-12. PMID: 28220411
3. A ERK/RSK-mediated negative feedback loop regulates M-CSF-evoked PI3K/AKT activation in macrophages.  |  Wang, L., et al. 2018. FASEB J. 32: 875-887. PMID: 29046360
4. Bim suppresses the development of SLE by limiting myeloid inflammatory responses.  |  Tsai, F., et al. 2017. J Exp Med. 214: 3753-3773. PMID: 29114065
5. Incomplete clearance of apoptotic cells by core 1-derived O-glycan-deficient resident peritoneal macrophages.  |  Wakui, H., et al. 2018. Biochem Biophys Res Commun. 495: 2017-2023. PMID: 29247646
6. Renal immune surveillance and dipeptidase-1 contribute to contrast-induced acute kidney injury.  |  Lau, A., et al. 2018. J Clin Invest. 128: 2894-2913. PMID: 29863495
7. Macrophage HIF-2α regulates tumor-suppressive Spint1 in the tumor microenvironment.  |  Susen, RM., et al. 2019. Mol Carcinog. 58: 2127-2138. PMID: 31436357
8. NLRP3 regulates alveolar bone loss in ligature-induced periodontitis by promoting osteoclastic differentiation.  |  Chen, Y., et al. 2021. Cell Prolif. 54: e12973. PMID: 33382502
9. Identification of prognostic biomarkers for papillary thyroid carcinoma by a weighted gene co-expression network analysis.  |  Meng, K., et al. 2022. Cancer Med. 11: 2006-2019. PMID: 35152572
10. Myeloid PHD2 deficiency accelerates neointima formation via Hif-1α.  |  Christoph, M., et al. 2022. Mol Immunol. 149: 48-58. PMID: 35724581

The preferred LYSMD1 antibody is LYSMD1 Antibody (G-3): sc-514030.