LPAAT-θ Antibody (F-7): sc-514163
- LPAAT-θ Antibody (F-7) is a mouse monoclonal IgG2b κ LPAAT-θ antibody provided at 200 µg/ml
- raised against amino acids 1-90 mapping at the N-terminus of LPAAT-θ of human origin
- LPAAT-theta Antibody (F-7) is recommended for detection of LPAAT-θ of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-LPAAT-theta Antibody (F-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LPAAT-θ Antibody (F-7) for WB applications. These reagents are now offered in bundles with LPAAT-θ Antibody (F-7) (see ordering information below).
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LPAAT-θ Antibody (F-7) is a mouse monoclonal IgG2b kappa light chain antibody that detects LPAAT-theta protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LPAAT-θ (F-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LPAAT-theta, or lysophosphatidic acid acyltransferase theta, plays a crucial role in lipid metabolism by catalyzing the conversion of lysophosphatidic acid to phosphatidic acid, a key intermediate in the biosynthesis of various lipids. This enzymatic activity maintains cellular membrane integrity and signaling pathways, as phosphatidic acid participates in numerous cellular processes, including cell growth, survival, and migration. LPAAT-theta is predominantly localized in the endoplasmic reticulum, expressing across various tissues, albeit at lower levels in the brain, kidney, liver, pancreas, placenta, prostate, and thymus. Notably, LPAAT-theta overexpression has been linked to the activation of signaling pathways that promote tumor progression, highlighting a potential role in cancer biology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LPAAT-θ Antibody (F-7) References:
- cDNA cloning, expression and chromosomal localization of two human lysophosphatidic acid acyltransferases. | Eberhardt, C., et al. 1999. Adv Exp Med Biol. 469: 351-6. PMID: 10667352
- Latency and duration of estrogen induction of maternal behavior in hysterectomized-ovariectomized virgin rats: effects of pup stimulation. | Siegel, HI. and Rosenblatt, JS. 1975. Physiol Behav. 14: 473-6. PMID: 1135291
- Identification of a novel human lysophosphatidic acid acyltransferase, LPAAT-theta, which activates mTOR pathway. | Tang, W., et al. 2006. J Biochem Mol Biol. 39: 626-35. PMID: 17002884
- Cloning and expression of two human lysophosphatidic acid acyltransferase cDNAs that enhance cytokine-induced signaling responses in cells. | West, J., et al. 1997. DNA Cell Biol. 16: 691-701. PMID: 9212163
- Human lysophosphatidic acid acyltransferase. cDNA cloning, expression, and localization to chromosome 9q34.3. | Eberhardt, C., et al. 1997. J Biol Chem. 272: 20299-305. PMID: 9242711
- Characterization of a human lysophosphatidic acid acyltransferase that is encoded by a gene located in the class III region of the human major histocompatibility complex. | Aguado, B. and Campbell, RD. 1998. J Biol Chem. 273: 4096-105. PMID: 9461603
- Interaction of lipopolysaccharide with a mammalian lyso-phosphatidate acyltransferase (LPAAT) transfected into E. coli, and effect of lisofylline on LPAAT transfected into mammalian cells. | Bursten, SL. 1998. Prog Clin Biol Res. 397: 345-56. PMID: 9575575
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LPAAT-θ Antibody (F-7) | sc-514163 | 200 µg/ml | $322.00 | |||
LPAAT-θ Antibody (F-7): m-IgG Fc BP-HRP Bundle | sc-531049 | 200 µg Ab; 10 µg BP | $361.00 | |||
LPAAT-θ Antibody (F-7): m-IgGκ BP-HRP Bundle | sc-524629 | 200 µg Ab, 40 µg BP | $361.00 | |||
LPAAT-θ Antibody (F-7): m-IgG2b BP-HRP Bundle | sc-550255 | 200 µg Ab; 10 µg BP | $361.00 | |||
LPAAT-θ Antibody (F-7) AC | sc-514163 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LPAAT-θ Antibody (F-7) HRP | sc-514163 HRP | 200 µg/ml | $322.00 | |||
LPAAT-θ Antibody (F-7) FITC | sc-514163 FITC | 200 µg/ml | $336.00 | |||
LPAAT-θ Antibody (F-7) PE | sc-514163 PE | 200 µg/ml | $349.00 | |||
LPAAT-θ Antibody (F-7) Alexa Fluor® 488 | sc-514163 AF488 | 200 µg/ml | $364.00 | |||
LPAAT-θ Antibody (F-7) Alexa Fluor® 546 | sc-514163 AF546 | 200 µg/ml | $364.00 | |||
LPAAT-θ Antibody (F-7) Alexa Fluor® 594 | sc-514163 AF594 | 200 µg/ml | $364.00 | |||
LPAAT-θ Antibody (F-7) Alexa Fluor® 647 | sc-514163 AF647 | 200 µg/ml | $364.00 | |||
LPAAT-θ Antibody (F-7) Alexa Fluor® 680 | sc-514163 AF680 | 200 µg/ml | $364.00 | |||
LPAAT-θ Antibody (F-7) Alexa Fluor® 790 | sc-514163 AF790 | 200 µg/ml | $364.00 |