LOXL4 Antibody (B-6): sc-365822

LOXL4 Antibody (B-6) is a mouse monoclonal IgG1 kappa light chain antibody that detects LOXL4 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LOXL4 (B-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LOXL4, a member of the lysyl oxidase family, plays a crucial role in the extracellular matrix by catalyzing the oxidative deamination of lysine residues, which is essential for the formation of cross-links in collagen and elastin. This process is vital for maintaining the structural integrity and mechanical properties of connective tissues. LOXL4 is predominantly localized in the extracellular space, but can also be found in the nucleus and cytoplasm, highlighting its multifaceted role in cellular processes. LOXL4 is highly expressed in tissues such as the testis, pancreas, cartilage, and skeletal muscle, indicating importance in various physiological functions, including tissue remodeling and development. Additionally, LOXL4 has been implicated in tumor suppression and cellular senescence, making LOXL4 a significant target for research in cancer biology and regenerative medicine.

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LOXL4 Antibody (B-6) References:

1. LOXL4 is a selectively expressed candidate diagnostic antigen in head and neck cancer.  |  Weise, JB., et al. 2008. Eur J Cancer. 44: 1323-31. PMID: 18499440
2. LOXL4 is downregulated in hepatocellular carcinoma with a favorable prognosis.  |  Tian, M., et al. 2015. Int J Clin Exp Pathol. 8: 3892-900. PMID: 26097573
3. LOXL4 knockdown enhances tumor growth and lung metastasis through collagen-dependent extracellular matrix changes in triple-negative breast cancer.  |  Choi, SK., et al. 2017. Oncotarget. 8: 11977-11989. PMID: 28060764
4. Exosome-mediated secretion of LOXL4 promotes hepatocellular carcinoma cell invasion and metastasis.  |  Li, R., et al. 2019. Mol Cancer. 18: 18. PMID: 30704479
5. Derepression of LOXL4 inhibits liver cancer growth by reactivating compromised p53.  |  Shao, J., et al. 2019. Cell Death Differ. 26: 2237-2252. PMID: 30728460
6. LOXL4 Abrogation Does Not Exaggerate Angiotensin II-Induced Thoracic or Abdominal Aortic Aneurysm in Mice.  |  Li, H., et al. 2021. Genes (Basel). 12: PMID: 33807332
7. LOXL4, but not LOXL2, is the critical determinant of pathological collagen cross-linking and fibrosis in the lung.  |  Ma, HY., et al. 2023. Sci Adv. 9: eadf0133. PMID: 37235663
8. The possibilities of LOXL4 as a prognostic marker for carcinomas.  |  Wang, J., et al. 2023. Amino Acids. 55: 1519-1529. PMID: 37814029
9. LOXL4 Shuttled by Tumor Cells-derived Extracellular Vesicles Promotes Immune Escape in Hepatocellular Carcinoma by Activating the STAT1/PD-L1 Axis.  |  Zhao, L., et al. J Immunother. 47: 64-76. PMID: 38047403
10. Bortezomib suppresses TGF-β1-mediated LOXL4 reduction through the inhibition of MEK/ERK pathways in MDA-MB-231 cells.  |  Kamiya, T., et al. 2025. J Recept Signal Transduct Res. 45: 73-82. PMID: 39862152

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LOXL4 Antibody (B-6) has 3 citations in a variety of scientific publications.

Primary antibodies like Anti-LOXL4 Antibody (B-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LOXL4 Antibody (B-6) Specifications

Alternate Product Name: LOXL4

Product Clone Name: B-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 211-280

Epitope Target: LOXL4

Epitope Species: human

Product Reactivity/Detection: LOXL4

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 3 citations in various scientific publications

Available Conjugates/Forms for LOXL4 Antibody (B-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred LOXL4 antibody is LOXL4 Antibody (D-11): sc-374121.