LNX2 Antibody (D-3): sc-398157

LNX2 Antibody (D-3) is a mouse monoclonal IgG2a antibody that detects LNX2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LNX2, also known as Ligand of Numb Protein X2, is a crucial protein that plays a significant role in cellular signaling and fate determination by interacting with the Numb and NumbL proteins. This interaction is vital as Numb is a key regulator in the asymmetric division of cells, influencing cell differentiation and development. LNX2 contains a RING finger domain, a PTB-binding motif, and four PDZ domains, which together facilitate function as a molecular scaffold. By promoting the aggregation of various interacting proteins, LNX2 helps localize these proteins to specific subcellular sites, thereby enhancing the efficiency of signaling pathways. The gene encoding LNX2 is located on chromosome 13q12.2, and expression patterns often overlap with those of Numb, suggesting a coordinated role in cellular processes. Additionally, the oligomerization of LNX2 and binding to Numb occur simultaneously, further emphasizing the importance in maintaining cellular organization and function. LNX2 (D-3) antibody is an essential tool for researchers studying the intricate mechanisms of cell signaling and differentiation.

The preferred LNX2 antibody is LNX2 Antibody (B-3): sc-398156.