LNX2 Antibody (B-3): sc-398156
- LNX2 Antibody (B-3) is a mouse monoclonal IgG2b κ LNX2 antibody provided at 200 µg/ml
- specific for an epitope mapping between amino acids 25-52 near the N-terminus of LNX2 of human origin
- LNX2 Antibody (B-3) is recommended for detection of LNX2 of mouse, rat, human and avian origin by WB, IP, IF and ELISA; also reactive with additional species, including canine and avian
- Anti-LNX2 Antibody (B-3) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for LNX2 Antibody (B-3) for WB applications. These reagents are now offered in bundles with LNX2 Antibody (B-3) (see ordering information below).
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LNX2 Antibody (B-3) is a mouse monoclonal IgG2b kappa light chain antibody that detects LNX2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LNX2 Antibody (B-3) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. LNX2, also known as LIGAND OF NUMB PROTEIN X2 or PDZ DOMAIN-CONTAINING RING FINGER PROTEIN 1, plays a crucial role in cellular signaling and fate determination by interacting with key proteins such as Numb and NumbL. Structurally, LNX2 features a RING finger domain, a PTB-binding motif, and four PDZ domains, which are essential for function as a molecular scaffold. This unique architecture allows LNX2 to facilitate the aggregation of various interacting proteins, directing them to specific subcellular locations, which is vital for maintaining cellular organization and function. LNX2 is located on chromosome 13q12.2, and expression patterns are closely associated with those of Numb proteins, suggesting participation in forming large protein networks through homomeric interactions. Additionally, research indicates that oligomerization of LNX2 and binding to Numb occur concurrently, highlighting the dynamic nature of these interactions in cellular processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
LNX2 Antibody (B-3) References:
- Identification of a human LNX protein containing multiple PDZ domains. | Xie, Y., et al. 2001. Biochem Genet. 39: 117-26. PMID: 11521506
- LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation. | Nie, J., et al. 2002. EMBO J. 21: 93-102. PMID: 11782429
- The Lnx family proteins function as molecular scaffolds for Numb family proteins. | Rice, DS., et al. 2001. Mol Cell Neurosci. 18: 525-40. PMID: 11922143
- Synthesis of arene-soluble mixed-metal Zr/Ce, Zr/Y, and related [[Zr2(OiPr)9]LnX2]n complexes using the dizirconium nonaisopropoxide ligand. | Evans, WJ., et al. 2000. Inorg Chem. 39: 2125-9. PMID: 12526523
- Identification and characterization of PDZRN3 and PDZRN4 genes in silico. | Katoh, M. and Katoh, M. 2004. Int J Mol Med. 13: 607-13. PMID: 15010864
- The cell surface protein coxsackie- and adenovirus receptor (CAR) directly associates with the Ligand-of-Numb Protein-X2 (LNX2). | Mirza, M., et al. 2005. Exp Cell Res. 309: 110-20. PMID: 15979067
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
LNX2 Antibody (B-3) | sc-398156 | 200 µg/ml | $322.00 | |||
LNX2 Antibody (B-3): m-IgG Fc BP-HRP Bundle | sc-530706 | 200 µg Ab; 10 µg BP | $361.00 | |||
LNX2 Antibody (B-3): m-IgGκ BP-HRP Bundle | sc-524234 | 200 µg Ab, 40 µg BP | $361.00 | |||
LNX2 Antibody (B-3): m-IgG2b BP-HRP Bundle | sc-550215 | 200 µg Ab; 10 µg BP | $361.00 | |||
LNX2 Antibody (B-3) AC | sc-398156 AC | 500 µg/ml, 25% agarose | $424.00 | |||
LNX2 Antibody (B-3) HRP | sc-398156 HRP | 200 µg/ml | $322.00 | |||
LNX2 Antibody (B-3) FITC | sc-398156 FITC | 200 µg/ml | $336.00 | |||
LNX2 Antibody (B-3) PE | sc-398156 PE | 200 µg/ml | $349.00 | |||
LNX2 Antibody (B-3) Alexa Fluor® 488 | sc-398156 AF488 | 200 µg/ml | $364.00 | |||
LNX2 Antibody (B-3) Alexa Fluor® 546 | sc-398156 AF546 | 200 µg/ml | $364.00 | |||
LNX2 Antibody (B-3) Alexa Fluor® 594 | sc-398156 AF594 | 200 µg/ml | $364.00 | |||
LNX2 Antibody (B-3) Alexa Fluor® 647 | sc-398156 AF647 | 200 µg/ml | $364.00 | |||
LNX2 Antibody (B-3) Alexa Fluor® 680 | sc-398156 AF680 | 200 µg/ml | $364.00 | |||
LNX2 Antibody (B-3) Alexa Fluor® 790 | sc-398156 AF790 | 200 µg/ml | $364.00 | |||
LNX2 (B-3) Neutralizing Peptide | sc-398156 P | 100 µg/0.5 ml | $69.00 |