LKB1 Antibody (Ley 37D/G6): sc-32245

LKB1 Antibody (Ley 37D/G6) is a mouse monoclonal IgG2b kappa light chain antibody designed to detect LKB1, also known as STK11 or serine/threonine kinase 11, across mouse, rat, and human species using western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP) techniques. LKB1 monoclonal antibody (Ley 37D/G6) targets an epitope on recombinant human LKB1, ensuring reliable recognition in various applications. LKB1 is a crucial serine/threonine kinase comprising 433 amino acids, playing a significant role in regulating cell metabolism, maintaining cellular energy homeostasis, and establishing cell polarity. LKB1 acts as a tumor suppressor by activating AMP-activated protein kinase (AMPK) and other related kinases, which are essential for controlling cell growth and proliferation. Mutations in LKB1 are strongly associated with Peutz-Jeghers Syndrome (PJS), a hereditary condition characterized by the development of benign polyps in the gastrointestinal tract, pigmented spots on the lips, and an elevated risk of several cancer types. Understanding LKB1′s function is vital for elucidating its role in tumor suppression and metabolic regulation, making anti-LKB1 antibody (Ley 37D/G6) an invaluable tool for research into cancer biology and metabolic diseases. Available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® variants, LKB1 (Ley 37D/G6) antibody provides versatile options for diverse experimental needs.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

LKB1 Antibody (Ley 37D/G6) References:

1. LKB1 tumor suppressor protein: PARtaker in cell polarity.  |  Baas, AF., et al. 2004. Trends Cell Biol. 14: 312-9. PMID: 15183188
2. LKB1 kinase: master and commander of metabolism and polarity.  |  Spicer, J. and Ashworth, A. 2004. Curr Biol. 14: R383-5. PMID: 15186763
3. The LKB1 tumor suppressor negatively regulates mTOR signaling.  |  Shaw, RJ., et al. 2004. Cancer Cell. 6: 91-9. PMID: 15261145
4. IGF-1 phosphorylates AMPK-alpha subunit in ATM-dependent and LKB1-independent manner.  |  Suzuki, A., et al. 2004. Biochem Biophys Res Commun. 324: 986-92. PMID: 15485651
5. Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase.  |  Jenne, DE., et al. 1998. Nat Genet. 18: 38-43. PMID: 9425897
6. A serine/threonine kinase gene defective in Peutz-Jeghers syndrome.  |  Hemminki, A., et al. 1998. Nature. 391: 184-7. PMID: 9428765
7. Low frequency of somatic mutations in the LKB1/Peutz-Jeghers syndrome gene in sporadic breast cancer.  |  Bignell, GR., et al. 1998. Cancer Res. 58: 1384-6. PMID: 9537235
8. Somatic mutations in LKB1 are rare in sporadic colorectal and testicular tumors.  |  Avizienyte, E., et al. 1998. Cancer Res. 58: 2087-90. PMID: 9605748
9. STK11 mutations in Peutz-Jeghers syndrome and sporadic colon cancer.  |  Resta, N., et al. 1998. Cancer Res. 58: 4799-801. PMID: 9809980
10. Loss of LKB1 kinase activity in Peutz-Jeghers syndrome, and evidence for allelic and locus heterogeneity.  |  Mehenni, H., et al. 1998. Am J Hum Genet. 63: 1641-50. PMID: 9837816

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-LKB1 Antibody (Ley 37D/G6) has 118 citations in a variety of scientific publications.

Primary antibodies like Anti-LKB1 Antibody (Ley 37D/G6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

LKB1 Antibody (Ley 37D/G6) Specifications

Alternate Product Name: STK11

Product Clone Name: Ley 37D/G6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: LKB1

Epitope Species: human

Product Reactivity/Detection: LKB1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P)

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 118 citations in various scientific publications

Available Conjugates/Forms for LKB1 Antibody (Ley 37D/G6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin