LETM1 Antibody (D-11): sc-514136

LETM1 Antibody (D-11) is a mouse monoclonal IgG2b antibody that detects LETM1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). LETM1, or leucine zipper-EF-hand-containing transmembrane protein 1, is a 739 amino acid protein localized to the mitochondrial membrane, where LETM1 plays a crucial role in maintaining mitochondrial function and overall cell viability. LETM1 features a leucine zipper motif, a transmembrane domain, and two EF-hand calcium-binding domains, which suggest LETM1′s involvement in calcium homeostasis within the mitochondria. This function is particularly important as calcium ions are vital for various cellular processes, including energy production and apoptosis regulation. LETM1 is expressed in all fetal and adult tissues, and human LETM1 shares 84% similarity with the mouse counterpart, indicating a conserved role across species. Notably, deletions in the gene encoding LETM1 are linked to Wolf-Hirschhorn syndrome, a congenital disorder characterized by multiple abnormalities such as mental retardation, seizures, and heart defects, underscoring LETM1′s significance in developmental biology and disease. Anti-LETM1 antibody (D-11) is an essential tool for researchers investigating mitochondrial dynamics and related pathologies.

The preferred LETM1 antibody is LETM1 Antibody (D-5): sc-271235.