Laminin α-2 Antibody (B-4): sc-55605

Laminin α-2 Antibody (B-4) is a mouse monoclonal IgG1 kappa light chain antibody that detects Laminin α-2 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Laminin α-2 antibody (B-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Laminin α-2 is a crucial component of basement membranes, which are specialized extracellular matrices that provide structural support to tissues and play a vital role in cellular functions. Laminin α-2 protein is composed of three chains—α, β, and γ—that form a heterotrimer, allowing for self-assembly and interaction with other matrix components. This structural versatility is essential for the formation and maintenance of basement membranes, which are found beneath epithelial cells, surrounding blood vessels, and enveloping muscle and nerve tissues. Proper assembly and function of Laminin α-2 are critical for muscle cell integrity, and mutations in Laminin α-2 gene are linked to congenital muscular dystrophy in humans, highlighting its importance in muscle development and maintenance. Laminin α-2 (B-4) monoclonal antibody is an invaluable tool for researchers studying this protein′s role in various biological processes and diseases, providing insights into its function and interactions within the extracellular matrix.

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Laminin α-2 Antibody (B-4) References:

1. Laminin {alpha}1 chain corrects male infertility caused by absence of laminin {alpha}2 chain.  |  Häger, M., et al. 2005. Am J Pathol. 167: 823-33. PMID: 16127160
2. Laminin alpha 2 enables glioblastoma stem cell growth.  |  Lathia, JD., et al. 2012. Ann Neurol. 72: 766-78. PMID: 23280793
3. Laminin α2-secreting fibroblasts enhance the therapeutic effect of skeletal myoblast sheets.  |  Uchinaka, A., et al. 2017. Eur J Cardiothorac Surg. 51: 457-464. PMID: 27663298
4. Electrical impedance myography in individuals with collagen 6 and laminin α-2 congenital muscular dystrophy: a cross-sectional and 2-year analysis.  |  Nichols, C., et al. 2018. Muscle Nerve. 57: 54-60. PMID: 28224647
5. Improving Reproducibility of Phenotypic Assessments in the DyW Mouse Model of Laminin-α2 Related Congenital Muscular Dystrophy.  |  Willmann, R., et al. 2017. J Neuromuscul Dis. 4: 115-126. PMID: 28550268
6. LAMA2 gene mutation update: Toward a more comprehensive picture of the laminin-α2 variome and its related phenotypes.  |  Oliveira, J., et al. 2018. Hum Mutat. 39: 1314-1337. PMID: 30055037
7. PDGFRβ-positive cell-mediated post-stroke remodeling of fibronectin and laminin α2 for tissue repair and functional recovery.  |  Shibahara, T., et al. 2023. J Cereb Blood Flow Metab. 43: 518-530. PMID: 36514952
8. Laminin-α2 chain deficiency in skeletal muscle causes dysregulation of multiple cellular mechanisms.  |  Martins, SG., et al. 2024. Life Sci Alliance. 7: PMID: 39379105
9. Preserved merosin M-chain (or laminin-alpha 2) expression in skeletal muscle distinguishes Walker-Warburg syndrome from Fukuyama muscular dystrophy and merosin-deficient congenital muscular dystrophy.  |  Voit, T., et al. 1995. Neuropediatrics. 26: 148-55. PMID: 7477753
10. Congenital muscular dystrophy with laminin alpha 2 chain deficiency: identification of a new intermediate phenotype and correlation of clinical findings to muscle immunohistochemistry.  |  Herrmann, R., et al. 1996. Eur J Pediatr. 155: 968-76. PMID: 8911899

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Laminin α-2 Antibody (B-4) has 13 citations in a variety of scientific publications.

Primary antibodies like Anti-Laminin α-2 Antibody (B-4) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Laminin α-2 Antibody (B-4) Specifications

Alternate Product Name: Laminin α-2

Product Clone Name: B-4

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 2811-2940

Epitope Target: Laminin α-2

Epitope Species: human

Product Reactivity/Detection: Laminin α-2

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 13 citations in various scientific publications

Available Conjugates/Forms for Laminin α-2 Antibody (B-4): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Laminin α-2 antibody is Laminin α-2 Antibody (4H8-2): sc-59854.