Laminin-5 Antibody (CM6): sc-32794
- Laminin-5 Antibody (CM6) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- mapping the globular (G) carboxy-terminal domain of the α-3 subunit of Laminin-5
- recommended for detection of α-3 subunit of Laminin-5, 6 and 7 of rat origin by WB, IP, IF and IHC(P); non cross-reactive with human or mouse α-3 chain
- also provided azide-free for prevents adhesion to rat α-3 subunit, sc-32794 L, 200 µg/0.1 ml
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Laminin-5 Antibody (CM6) for WB and IHC(P) applications. These reagents are now offered in bundles with Laminin-5 Antibody (CM6) (see ordering information below).
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Laminin-5 Antibody (CM6) is a mouse monoclonal IgG1 antibody that detects Laminin-5 in rat samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry with paraffin-embedded sections (IHCP). Laminin-5 is a crucial glycoprotein complex composed of three subunits: laminin-alpha3, laminin-beta3, and laminin-gamma2, which play a significant role in cell adhesion, signal transduction, and keratinocyte differentiation. Laminin-5 is primarily located in the basal lamina beneath epithelial tissues, where anti-Laminin-5 antibody (CM6) can detect anchoring basal epithelial cells to the extracellular matrix (ECM). The structural integrity of Laminin-5 is vital for maintaining tissue architecture and function, as Laminin-5 influences how cells interact with their surrounding environment. Notably, differential processing of the Laminin-5 precursor subunits can affect ECM integration, thereby impacting cellular behavior and tissue homeostasis. Laminin-5 (CM6) antibody serves as an invaluable tool for researchers studying the dynamics of cell adhesion and the molecular mechanisms underlying epithelial integrity and pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Laminin-5 Antibody (CM6) References:
- Laminin-5-mediated gene expression in human prostate carcinoma cells. | Calaluce, R., et al. 2001. Mol Carcinog. 30: 119-29. PMID: 11241759
- Laminin-5 gamma2 chain expression as a possible determinant of tumor aggressiveness in T1 colorectal carcinomas. | Masaki, T., et al. 2003. Dig Dis Sci. 48: 272-8. PMID: 12643602
- Laminin-5 gamma2 chain in cryptogenic organizing pneumonia and idiopathic pulmonary fibrosis. | Lappi-Blanco, E., et al. 2004. Am J Respir Crit Care Med. 169: 27-33. PMID: 14500258
- Usefulness of immunoblotting using purified laminin 5 in the diagnosis of anti-laminin 5 cicatricial pemphigoid. | Hisamatsu, Y., et al. 2003. J Dermatol Sci. 33: 113-9. PMID: 14581137
- Globular domains 4/5 of the laminin alpha3 chain mediate deposition of precursor laminin 5. | Sigle, RO., et al. 2004. J Cell Sci. 117: 4481-94. PMID: 15316072
- Laminin-5 induces osteogenic gene expression in human mesenchymal stem cells through an ERK-dependent pathway. | Klees, RF., et al. 2005. Mol Biol Cell. 16: 881-90. PMID: 15574877
- Laminin-5 and type I collagen promote adhesion and osteogenic differentiation of animal serum-free expanded human mesenchymal stromal cells. | Mittag, F., et al. 2012. Orthop Rev (Pavia). 4: e36. PMID: 23589764
- Laminin-5 and insulin-like growth factor-II mRNA binding protein-3 (IMP3) expression in preoperative biopsy specimens from oral cancer patients: Their role in neural spread risk and survival stratification. | Tarsitano, A., et al. 2016. J Craniomaxillofac Surg. 44: 1896-1902. PMID: 27863864
- Clinical significance of fascin-1 and laminin-5 in non-small cell lung cancer. | Yang, L., et al. 2017. Genet Mol Res. 16: PMID: 28653739
- Collagen XVII/laminin-5 activates epithelial-to-mesenchymal transition and is associated with poor prognosis in lung cancer. | Liu, CC., et al. 2018. Oncotarget. 9: 1656-1672. PMID: 29416721
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Laminin-5 Antibody (CM6) | sc-32794 | 200 µg/ml | $316.00 | |||
Laminin-5 Antibody (CM6): m-IgG Fc BP-HRP Bundle | sc-536749 | 200 µg Ab; 10 µg BP | $354.00 | |||
Laminin-5 Antibody (CM6): m-IgGκ BP-HRP Bundle | sc-533912 | 200 µg Ab; 40 µg BP | $354.00 | |||
Laminin-5 Antibody (CM6): m-IgG1 BP-HRP Bundle | sc-544795 | 200 µg Ab; 20 µg BP | $354.00 | |||
Laminin-5 Antibody (CM6) L | sc-32794 L | 200 µg/0.1 ml | $316.00 |