Lamin A/C Antibody (2A1): sc-517580

Lamin A/C Antibody (2A1) is a mouse monoclonal IgG2b antibody that detects Lamin A/C in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Lamin A/C plays a crucial role in maintaining the structural integrity of the nuclear envelope, which is essential for proper cellular function and organization. Lamin A/C is located in the nuclear lamina, a dense fibrillar network inside the nucleus, where Lamin A/C provides mechanical support and regulates important processes such as DNA replication and cell division. The significance of Lamin A/C extends beyond structural support; Lamin A/C is also involved in chromatin organization and gene expression regulation. Disruptions in Lamin A/C function can lead to various diseases, including muscular dystrophies and progeria, highlighting Lamin A/C′s importance in cellular health and longevity. Lamin A is cleaved by the protease Mch2 during apoptosis, while Lamin C, a splice variant of Lamin A, shares a high degree of similarity with Lamin A but differs at the carboxy-terminus, which may influence specific interactions and functions within the cell. Anti-Lamin A/C antibody (2A1) serves as an invaluable tool for researchers studying the dynamics of the nuclear envelope and its implications in cellular processes and disease states.

The preferred Lamin A/C antibody is Lamin A/C Antibody (636): sc-7292.