L3MBTL Antibody (D-10): sc-398603

L3MBTL Antibody (D-10) is a mouse monoclonal IgG1 antibody that detects L3MBTL in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). L3MBTL is a crucial member of the Polycomb group of proteins, functioning primarily as a transcriptional repressor within large protein complexes, which is vital for the regulation of gene expression patterns. L3MBTL features three MBT repeats, each consisting of 100 residues, along with a C-terminal alpha-helical structure that resides within a cavity lined by aromatic amino acids, contributing to structural integrity and functional specificity. L3MBTL undergoes monoallelic methylation in hematopoietic tissues, a modification that plays a significant role in regulatory functions. During interphase, L3MBTL is predominantly localized in the nucleus, where L3MBTL associates with condensed chromosomes during mitosis, highlighting importance in cell division and gene regulation. The human L3MBTL gene is located on chromosome 20, a region often deleted in patients with myeloid malignancies, suggesting L3MBTL may act as a tumor suppressor gene and implicating expression in certain cases of myeloid leukemia. Anti-L3MBTL antibody (D-10) effectively detects this target, making L3MBTL antibody (D-10) an essential tool for researchers studying gene regulation and cancer biology.

The preferred L3MBTL antibody is L3MBTL Antibody (D-9): sc-166905.