L-Selectin/CD62L/SELL Antibody (OX85): sc-53087
- L-Selectin/CD62L/SELL Antibody (OX85) is a mouse monoclonal IgG1 κ provided at 200 µg/ml
- raised against purified L-Selectin-CD4 of rat origin
- recommended for detection of L-Selectin of mouse and rat origin by FCM
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for L-Selectin/CD62L/SELL Antibody (OX85). This reagent is now offered in a bundle with L-Selectin/CD62L/SELL Antibody (OX85) (see ordering information below).
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L-Selectin Antibody (OX85) is a mouse monoclonal IgG1 kappa light chain antibody that detects L-Selectin protein of mouse and rat origin by flow cytometry (FCM). L-Selectin, also known as LECAM-1 or CD62L, plays a crucial role in the immune response by facilitating leukocyte adhesion to the endothelium, which is essential for immune cell migration to sites of inflammation or injury. L-Selectin (OX85) antibody recognizes a protein predominantly expressed on naive T cells, B cells, monocytes, neutrophils, and eosinophils, highlighting L-Selectin′s importance in immune cell trafficking regulation. L-Selectin interacts with specific carbohydrates on activated endothelial cells, enabling leukocytes to roll along the vessel wall and eventually extravasate into tissues. L-Selectin shares overlapping ligand specificities with other selectins, such as P-Selectin and E-Selectin, which further underscores L-Selectin′s significance in mediating cellular interactions during immune responses. Anti-L-Selectin antibody (OX85) serves as an invaluable tool for researchers studying immune cell behavior and mechanisms underlying inflammation and immune responses.
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L-Selectin/CD62L/SELL Antibody (OX85) References:
- Signals regulating L-selectin-dependent leucocyte adhesion and transmigration. | Ivetic, A. 2013. Int J Biochem Cell Biol. 45: 550-5. PMID: 23299028
- L-selectin deficiency decreases aortic B1a and Breg subsets and promotes atherosclerosis. | Gjurich, BN., et al. 2014. Thromb Haemost. 112: 803-11. PMID: 24989887
- L-selectin mechanochemistry restricts neutrophil priming in vivo. | Liu, Z., et al. 2017. Nat Commun. 8: 15196. PMID: 28497779
- A head-to-tail view of L-selectin and its impact on neutrophil behaviour. | Ivetic, A. 2018. Cell Tissue Res. 371: 437-453. PMID: 29353325
- L-selectin: A Major Regulator of Leukocyte Adhesion, Migration and Signaling. | Ivetic, A., et al. 2019. Front Immunol. 10: 1068. PMID: 31139190
- L-Selectin Enhanced T Cells Improve the Efficacy of Cancer Immunotherapy. | Watson, HA., et al. 2019. Front Immunol. 10: 1321. PMID: 31249570
- L-selectin activation regulates Rho GTPase activity via Ca+2 influx in Sertoli cell line, Asc-17D cells. | Limanjaya, I., et al. 2020. Biochem Biophys Res Commun. 525: 1011-1017. PMID: 32178872
- Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment. | Zhao, Y., et al. 2023. Adv Sci (Weinh). 10: e2300738. PMID: 37170724
- LncRNA SELL/L-selectin promotes HPV-positive HNSCC progression and drives fucoidan-mediated therapeutic strategies. | Wang, S., et al. 2023. Acta Biomater. 167: 436-448. PMID: 37330030
- L-selectin expression in CD34 positive cells in chronic myeloid leukemia. | Kimura, A., et al. 1998. Leuk Lymphoma. 28: 399-404. PMID: 9517512
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
L-Selectin/CD62L/SELL Antibody (OX85) | sc-53087 | 200 µg/ml | $322.00 | |||
L-Selectin/CD62L/SELL Antibody (OX85): m-IgG Fc BP-HRP Bundle | sc-538973 | 200 µg Ab; 10 µg BP | $361.00 | |||
L-Selectin/CD62L/SELL Antibody (OX85) FITC | sc-53087 FITC | 200 µg/ml | $336.00 | |||
L-Selectin/CD62L/SELL Antibody (OX85) PE | sc-53087 PE | 200 µg/ml | $349.00 |