Ku70 Antibody (3F246): sc-71469
- Ku70 Antibody (3F246) is a mouse monoclonal IgG2b κ, cited in 1 publications, provided at 200 µg/ml
- raised against PSE1-PL human placental cells
- recommended for detection of Ku70 of mouse, rat, human and Xenopus origin by WB, IP, IF and IHC(P)
- See Ku70 (E-5): sc-17789 for Ku70 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP is the preferred secondary detection reagent for Ku70 Antibody (3F246) for WB and IHC(P) applications. This reagent is now offered in a bundle with Ku70 Antibody (3F246) (see ordering information below).
Ku70 Antibody (3F246) is a mouse monoclonal IgG2b antibody that detects Ku70 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Ku70 is a crucial component of the Ku protein complex, which is essential for DNA repair and maintenance of genomic stability. Ku70 is primarily localized in the nucleus, where Ku70 plays a vital role in the non-homologous end joining (NHEJ) pathway, a key mechanism for repairing double-strand breaks in DNA. Nuclear localization of Ku70 ensures ready availability to bind to DNA ends and facilitate the repair process, thereby preventing genomic instability that can lead to cancer and other diseases. Ku70 interacts with its partner subunit, Ku86, to form a heterodimer that exhibits DNA-binding activity, which is critical for recruiting additional repair factors to the site of damage. The Ku70/Ku86 complex is involved in regulating transcription and maintaining telomere integrity, highlighting its multifaceted role in cellular function. Anti-Ku70 antibody (3F246) is an invaluable tool for researchers studying DNA repair mechanisms and related cellular processes.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ku70 Antibody (3F246) | sc-71469 | 200 µg/ml | $316.00 | |||
Ku70 Antibody (3F246): m-IgG Fc BP-HRP Bundle | sc-551967 | 200 µg Ab; 10 µg BP | $354.00 |