Ku70 Antibody (0.N.376): sc-71470
- Ku70 Antibody (0.N.376) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against placental cell extract of human origin
- recommended for detection of Ku70 of mouse, rat and human origin by WB, IP, IF and IHC(P)
- See Ku70 (E-5): sc-17789 for Ku70 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for Ku70 Antibody (0.N.376) for WB and IHC(P) applications. These reagents are now offered in bundles with Ku70 Antibody (0.N.376) (see ordering information below).
Ku70 Antibody (0.N.376) is a mouse monoclonal IgG1 antibody that detects Ku70 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and immunohistochemistry. Ku70 is a critical component of the Ku protein complex, which is essential for DNA repair and maintenance of genomic stability. Ku70 is primarily localized in the nucleus, where anti-Ku70 antibody (0.N.376) can detect its pivotal role in the non-homologous end joining (NHEJ) pathway, a key mechanism for repairing double-strand breaks in DNA. Nuclear localization of Ku70 ensures ready availability to bind DNA ends and facilitate repair processes, thereby preventing genomic instability that can lead to cancer and other diseases. Additionally, Ku70 interacts with Ku86 to form a heterodimer exhibiting DNA-binding activity, crucial for recruiting repair factors and activating DNA-dependent protein kinase. Ku70 (0.N.376) antibody serves as an invaluable tool for researchers studying DNA repair mechanisms, cellular responses to DNA damage, and the role of Ku proteins in various diseases.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ku70 Antibody (0.N.376) | sc-71470 | 200 µg/ml | $316.00 | |||
Ku70 Antibody (0.N.376): m-IgG Fc BP-HRP Bundle | sc-539369 | 200 µg Ab; 10 µg BP | $354.00 | |||
Ku70 Antibody (0.N.376): m-IgG1 BP-HRP Bundle | sc-541441 | 200 µg Ab; 20 µg BP | $354.00 |