KLC3 Antibody (E-7): sc-398332
- KLC3 Antibody (E-7) is a mouse monoclonal IgG1 κ KLC3 antibody, cited in 2 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 171-192 within an internal region of KLC3 of human origin
- KLC3 Antibody (E-7) is recommended for detection of KLC3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including bovine
- Anti-KLC3 Antibody (E-7) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KLC3 Antibody (E-7) for WB applications. These reagents are now offered in bundles with KLC3 Antibody (E-7) (see ordering information below).
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KLC3 Antibody (E-7) is a mouse monoclonal IgG1 kappa light chain antibody that detects KLC3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KLC3 (E-7) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KLC3, also known as kinesin light chain 3, is a 504 amino acid protein characterized by five tetratricopeptide repeats and is a vital component of the kinesin family of motor proteins. These proteins are essential for intracellular transport, playing a significant role in the distribution of organelles, vesicles, and macromolecular complexes within cells. KLC3 functions as a microtubule-associated protein, generating mechanical force necessary for organelle transport, and is part of a larger oligomeric structure composed of heavy and light chains. KLC3′s importance extends to involvement in various cellular processes, including cell division and membrane trafficking events such as endocytosis and transcytosis. Notably, KLC3 undergoes alternative splicing, resulting in multiple isoforms that may have distinct functional roles, further underscoring this protein′s complexity and significance in cellular dynamics.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KLC3 Antibody (E-7) References:
- Defective kinesin heavy chain behavior in mouse kinesin light chain mutants. | Rahman, A., et al. 1999. J Cell Biol. 146: 1277-88. PMID: 10491391
- Kinesin light-chain KLC3 expression in testis is restricted to spermatids. | Junco, A., et al. 2001. Biol Reprod. 64: 1320-30. PMID: 11319135
- Phosphorylation-dependent interaction of kinesin light chain 2 and the 14-3-3 protein. | Ichimura, T., et al. 2002. Biochemistry. 41: 5566-72. PMID: 11969417
- Association of kinesin light chain with outer dense fibers in a microtubule-independent fashion. | Bhullar, B., et al. 2003. J Biol Chem. 278: 16159-68. PMID: 12594206
- Rat kinesin light chain 3 associates with spermatid mitochondria. | Zhang, Y., et al. 2004. Dev Biol. 275: 23-33. PMID: 15464570
- Conventional kinesin holoenzymes are composed of heavy and light chain homodimers. | DeBoer, SR., et al. 2008. Biochemistry. 47: 4535-43. PMID: 18361505
- Sequence analysis of the ERCC2 gene regions in human, mouse, and hamster reveals three linked genes. | Lamerdin, JE., et al. 1996. Genomics. 34: 399-409. PMID: 8786141
- Two kinesin light chain genes in mice. Identification and characterization of the encoded proteins. | Rahman, A., et al. 1998. J Biol Chem. 273: 15395-403. PMID: 9624122
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KLC3 Antibody (E-7) | sc-398332 | 200 µg/ml | $316.00 | |||
KLC3 Antibody (E-7): m-IgG Fc BP-HRP Bundle | sc-530761 | 200 µg Ab; 10 µg BP | $354.00 | |||
KLC3 Antibody (E-7): m-IgGκ BP-HRP Bundle | sc-524296 | 200 µg Ab, 40 µg BP | $354.00 | |||
KLC3 Antibody (E-7): m-IgG1 BP-HRP Bundle | sc-544241 | 200 µg Ab; 20 µg BP | $354.00 | |||
KLC3 Antibody (E-7) AC | sc-398332 AC | 500 µg/ml, 25% agarose | $416.00 | |||
KLC3 Antibody (E-7) HRP | sc-398332 HRP | 200 µg/ml | $316.00 | |||
KLC3 Antibody (E-7) FITC | sc-398332 FITC | 200 µg/ml | $330.00 | |||
KLC3 Antibody (E-7) PE | sc-398332 PE | 200 µg/ml | $343.00 | |||
KLC3 Antibody (E-7) Alexa Fluor® 488 | sc-398332 AF488 | 200 µg/ml | $357.00 | |||
KLC3 Antibody (E-7) Alexa Fluor® 546 | sc-398332 AF546 | 200 µg/ml | $357.00 | |||
KLC3 Antibody (E-7) Alexa Fluor® 594 | sc-398332 AF594 | 200 µg/ml | $357.00 | |||
KLC3 Antibody (E-7) Alexa Fluor® 647 | sc-398332 AF647 | 200 µg/ml | $357.00 | |||
KLC3 Antibody (E-7) Alexa Fluor® 680 | sc-398332 AF680 | 200 µg/ml | $357.00 | |||
KLC3 Antibody (E-7) Alexa Fluor® 790 | sc-398332 AF790 | 200 µg/ml | $357.00 | |||
KLC3 (E-7) Neutralizing Peptide | sc-398332 P | 100 µg/0.5 ml | $68.00 |