IP3R-I Antibody (E-8): sc-271197
- IP3R-I Antibody (E-8) is a mouse monoclonal IgG1 κ IP3R-I antibody, cited in 24 publications, provided at 200 µg/ml
- raised against amino acids 1894-1973 mapping within a cytoplasmic domain of IP3R-I of human origin
- IP3R-I Antibody (E-8) is recommended for detection of IP3R-I of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-IP3R-I Antibody (E-8) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IP3R-I Antibody (E-8) for WB and IHC(P) applications. These reagents are now offered in bundles with IP3R-I Antibody (E-8) (see ordering information below).
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IP3R-I Antibody (E-8) is a mouse monoclonal IgG1 kappa light chain antibody engineered to target the inositol 1,4,5-trisphosphate receptor type I (IP3R-I), also known as INSP3R1 or IP3R1. IP3R-I monoclonal antibody (E-8) is raised against amino acids 1894-1973 within the cytoplasmic domain of the human IP3R-I protein, ensuring precise recognition and binding. IP3R-I functions as a critical intracellular receptor for inositol 1,4,5-trisphosphate (IP3), acting as a calcium release channel that mediates calcium signaling in various cell types. This function is essential for regulating diverse cellular processes, including exocrine secretion, energy metabolism, and neuronal activity, making IP3R-I a vital component in the central nervous system and liver. Anti-IP3R-I antibody (E-8) demonstrates broad species reactivity, effectively detecting IP3R-I from mouse, rat, and human origins across multiple applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Additionally, IP3R-I (E-8) antibody is available in both non-conjugated form and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing flexibility for diverse experimental needs. By targeting the predominant IP3R subtype in neuronal tissues, IP3R-I (E-8) monoclonal antibody facilitates in-depth studies of calcium signaling pathways and their implications in neurological and hepatic functions.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IP3R-I Antibody (E-8) References:
- In situ hybridization of mRNA expression for IP3 receptor and IP3-3-kinase in rat brain after transient focal cerebral ischemia. | Zhang, SX., et al. 1995. Brain Res Mol Brain Res. 32: 252-60. PMID: 7500836
- The inositol 1,4,5-triphosphate receptor expression in Drosophila suggests a role for IP3 signalling in muscle development and adult chemosensory functions. | Raghu, P. and Hasan, G. 1995. Dev Biol. 171: 564-77. PMID: 7556937
- Heteroligomers of type-I and type-III inositol trisphosphate receptors in WB rat liver epithelial cells. | Joseph, SK., et al. 1995. J Biol Chem. 270: 23310-6. PMID: 7559486
- Sequence and functional characterization of a third inositol trisphosphate receptor subtype, IP3R-3, expressed in pancreatic islets, kidney, gastrointestinal tract, and other tissues. | Blondel, O., et al. 1993. J Biol Chem. 268: 11356-63. PMID: 8388391
- Calcineurin associated with the inositol 1,4,5-trisphosphate receptor-FKBP12 complex modulates Ca2+ flux. | Cameron, AM., et al. 1995. Cell. 83: 463-72. PMID: 8521476
- Ataxia and epileptic seizures in mice lacking type 1 inositol 1,4,5-trisphosphate receptor. | Matsumoto, M., et al. 1996. Nature. 379: 168-71. PMID: 8538767
- Regulation of the inositol 1,4,5-trisphosphate receptor by tyrosine phosphorylation. | Jayaraman, T., et al. 1996. Science. 272: 1492-4. PMID: 8633244
- Lymphocyte apoptosis: mediation by increased type 3 inositol 1,4,5-trisphosphate receptor. | Khan, AA., et al. 1996. Science. 273: 503-7. PMID: 8662540
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IP3R-I Antibody (E-8) | sc-271197 | 200 µg/ml | $322.00 | |||
IP3R-I Antibody (E-8): m-IgG Fc BP-HRP Bundle | sc-529137 | 200 µg Ab; 10 µg BP | $361.00 | |||
IP3R-I Antibody (E-8): m-IgGκ BP-HRP Bundle | sc-521873 | 200 µg Ab, 40 µg BP | $361.00 | |||
IP3R-I Antibody (E-8): m-IgG1 BP-HRP Bundle | sc-543343 | 200 µg Ab; 20 µg BP | $361.00 | |||
IP3R-I Antibody (E-8) AC | sc-271197 AC | 500 µg/ml, 25% agarose | $424.00 | |||
IP3R-I Antibody (E-8) HRP | sc-271197 HRP | 200 µg/ml | $322.00 | |||
IP3R-I Antibody (E-8) FITC | sc-271197 FITC | 200 µg/ml | $336.00 | |||
IP3R-I Antibody (E-8) PE | sc-271197 PE | 200 µg/ml | $349.00 | |||
IP3R-I Antibody (E-8) Alexa Fluor® 488 | sc-271197 AF488 | 200 µg/ml | $364.00 | |||
IP3R-I Antibody (E-8) Alexa Fluor® 546 | sc-271197 AF546 | 200 µg/ml | $364.00 | |||
IP3R-I Antibody (E-8) Alexa Fluor® 594 | sc-271197 AF594 | 200 µg/ml | $364.00 | |||
IP3R-I Antibody (E-8) Alexa Fluor® 647 | sc-271197 AF647 | 200 µg/ml | $364.00 | |||
IP3R-I Antibody (E-8) Alexa Fluor® 680 | sc-271197 AF680 | 200 µg/ml | $364.00 | |||
IP3R-I Antibody (E-8) Alexa Fluor® 790 | sc-271197 AF790 | 200 µg/ml | $364.00 |