Integrin α7/ITGA7 Antibody (E-2): sc-515716

Integrin α7 Antibody (E-2) is an IgG₁ κ mouse monoclonal Integrin alpha 7 antibody (also designated Integrin alpha-7 antibody or ITGA7 antibody) that detects the Integrin alpha 7 protein of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA. Integrin α7 Antibody (E-2) is available as both the non-conjugated anti-Integrin alpha 7 antibody form, as well as multiple conjugated forms of anti-Integrin alpha 7 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor^® conjugates. Integrins are heterodimers composed of noncovalently associated transmembrane α and β subunits. The 16 α and 8 β subunits heterodimerize to produce more than 20 different receptors. Most integrin receptors bind ligands that are components of the extracellular matrix, including fibronectin, collagen and vitronectin. Certain integrins can also bind to soluble ligands such as fibrinogen, or to counterreceptors on adjacent cells such as the intracellular adhesion molecules (ICAMs), leading to aggregation of cells. Ligands serve to cross-link or cluster integrins by binding to adjacent integrin receptors; both receptor clustering and ligand occupancy are necessary for the activation of integrin-mediated responses. In addition to mediating cell adhesion and cytoskeletal organization, integrins function as signaling receptors. Signals transduced by integrins play a role in many biological processes, including cell growth, differentiation, migration and apoptosis.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Integrin α7/ITGA7 Antibody (E-2) References:

1. Analysis of integrin alpha7 mutations in prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma.  |  Ren, B., et al. 2007. J Natl Cancer Inst. 99: 868-80. PMID: 17551147
2. Integrin α7 binds tissue inhibitor of metalloproteinase 3 to suppress growth of prostate cancer cells.  |  Tan, LZ., et al. 2013. Am J Pathol. 183: 831-40. PMID: 23830872
3. S100P interacts with integrin α7 and increases cancer cell migration and invasion in lung cancer.  |  Hsu, YL., et al. 2015. Oncotarget. 6: 29585-98. PMID: 26320193
4. Deletion of integrin α7 subunit does not aggravate the phenotype of laminin α2 chain-deficient mice.  |  Gawlik, KI. and Durbeej, M. 2015. Sci Rep. 5: 13916. PMID: 26355035
5. Integrin α7 is a functional cancer stem cell surface marker in oesophageal squamous cell carcinoma.  |  Ming, XY., et al. 2016. Nat Commun. 7: 13568. PMID: 27924820
6. Integrin α7 expression is increased in asthmatic patients and its inhibition reduces Kras protein abundance in airway smooth muscle cells.  |  Teoh, CM., et al. 2019. Sci Rep. 9: 9892. PMID: 31289310
7. Integrin α7 is overexpressed and correlates with higher pathological grade, increased T stage, advanced TNM stage as well as worse survival in clear cell renal cell carcinoma patients: A retrospective study.  |  Chen, Y., et al. 2020. J Clin Lab Anal. 34: e23034. PMID: 31713264
8. Overexpression of integrin α7 correlates with advanced disease condition and poor prognosis in rectal cancer patients.  |  Huang, J., et al. 2018. Int J Clin Exp Pathol. 11: 4630-4636. PMID: 31949862
9. Angiogenic factor AGGF1 blocks neointimal formation after vascular injury via interaction with integrin α7 on vascular smooth muscle cells.  |  Yu, Y., et al. 2022. J Biol Chem. 298: 101759. PMID: 35202649
10. Effect of integrin α7 on cell proliferation, invasion, apoptosis and the PI3K/AKT pathway, and its association with clinicopathological features in endometrial cancer.  |  Liang, M., et al. 2023. Oncol Lett. 25: 26. PMID: 36478908

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α7/ITGA7 Antibody (E-2) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α7/ITGA7 Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α7/ITGA7 Antibody (E-2) Specifications

Alternate Product Name: Integrin α7

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 878-917

Epitope Target: Integrin α7

Epitope Species: human

Product Reactivity/Detection: precursor and mature heavy chain Integrin α7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Integrin α7/ITGA7 Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, B: Biotin, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred Integrin α7/ITGA7 antibody is Integrin α7/ITGA7 Antibody (012-Z): sc-81807.