Integrin α7/ITGA7 Antibody (012-Z): sc-81807

Integrin α7 Antibody (012-Z) is a mouse monoclonal IgG2a kappa light chain antibody that detects Integrin α7 in mouse, rat, and human samples through western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA). Anti-Integrin α7 antibody (012-Z) is available in a non-conjugated form, allowing for versatile applications in various experimental setups. Integrin α7 is a crucial component of the integrin family, which consists of heterodimers formed by noncovalently associated transmembrane α and β subunits. Integrin α7 monoclonal antibody (012-Z) recognizes a protein particularly significant in muscle tissue, where Integrin α7 plays a vital role in mediating cell adhesion and signaling pathways essential for muscle development and repair. Integrin α7 interacts with components of the extracellular matrix, such as laminin, which is critical for maintaining the structural integrity of muscle fibers. This interaction not only facilitates cell adhesion but also triggers intracellular signaling cascades that promote muscle cell survival, differentiation, and migration. Understanding Integrin α7 function is important for elucidating mechanisms underlying muscle diseases and injuries, making Integrin α7 (012-Z) antibody an invaluable tool for researchers studying muscle biology and related pathologies.

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Integrin α7/ITGA7 Antibody (012-Z) References:

1. Integrins: versatility, modulation, and signaling in cell adhesion.  |  Hynes, RO. 1992. Cell. 69: 11-25. PMID: 1555235
2. Expression of α5-integrin, α7-integrin, Ε-cadherin, and N-cadherin in localized prostate cancer.  |  Drivalos, A., et al. 2016. Urol Oncol. 34: 165.e11-8. PMID: 26652134
3. Integrin α7 Is a Functional Marker and Potential Therapeutic Target in Glioblastoma.  |  Haas, TL., et al. 2017. Cell Stem Cell. 21: 35-50.e9. PMID: 28602620
4. Integrin α7: a major driver and therapeutic target for glioblastoma malignancy.  |  Nunes, AM., et al. 2017. Stem Cell Investig. 4: 97. PMID: 29359136
5. Integrin-α7 signaling regulates connexin 43, M-cadherin, and myoblast fusion.  |  McClure, MJ., et al. 2019. Am J Physiol Cell Physiol. 316: C876-C887. PMID: 30892939
6. Integrin α7 knockdown suppresses cell proliferation, migration, invasion and EMT in hepatocellular carcinoma.  |  Wu, Z., et al. 2021. Exp Ther Med. 21: 309. PMID: 33717252
7. Integrin α7 Mutations Are Associated With Adult-Onset Cardiac Dysfunction in Humans and Mice.  |  Bugiardini, E., et al. 2022. J Am Heart Assoc. 11: e026494. PMID: 36444867
8. AGGF1 therapy inhibits thoracic aortic aneurysms by enhancing integrin α7-mediated inhibition of TGF-β1 maturation and ERK1/2 signaling.  |  Da, X., et al. 2023. Nat Commun. 14: 2265. PMID: 37081014
9. Integrins and signal transduction pathways: the road taken.  |  Clark, EA. and Brugge, JS. 1995. Science. 268: 233-9. PMID: 7716514
10. Synergistic roles for receptor occupancy and aggregation in integrin transmembrane function.  |  Miyamoto, S., et al. 1995. Science. 267: 883-5. PMID: 7846531
11. Epithelial integrins.  |  Sheppard, D. 1996. Bioessays. 18: 655-60. PMID: 8760339
12. Cooperation between soluble factors and integrin-mediated cell anchorage in the control of cell growth and differentiation.  |  Juliano, R. 1996. Bioessays. 18: 911-7. PMID: 8939069

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-Integrin α7/ITGA7 Antibody (012-Z) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-Integrin α7/ITGA7 Antibody (012-Z) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

Integrin α7/ITGA7 Antibody (012-Z) Specifications

Alternate Product Name: Integrin α7

Product Clone Name: 012-Z

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids: 478-578

Epitope Target: Integrin α7

Epitope Species: human

Product Reactivity/Detection: Integrin α7

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, ELISA

Vialing Information: Each vial contains 100 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for Integrin α7/ITGA7 Antibody (012-Z): N/A

The preferred Integrin α7/ITGA7 antibody is Integrin α7/ITGA7 Antibody (E-2): sc-515716.