INSR/Insulin Receptor β Antibody (11B6 ): sc-81465

Insulin Rβ Antibody (11B6) is a mouse monoclonal IgG1 antibody engineered to target the C-terminus of the human insulin receptor beta subunit. Insulin Rβ monoclonal antibody (11B6) effectively detects the insulin receptor beta (INSR) protein from mouse, rat, human, and canine origins through applications such as western blotting (WB) and immunoprecipitation (IP), ensuring reliable performance in various research settings. The insulin receptor is a crucial transmembrane protein complex located on the cell surface, where it plays a pivotal role in mediating the cellular response to insulin. Comprising an extracellular alpha subunit and an intracellular beta subunit connected by disulfide bonds, the insulin receptor facilitates the binding of insulin, which triggers a cascade of intracellular signaling pathways essential for glucose uptake, glycogen synthesis, and overall metabolic regulation. Upon insulin binding, the receptor undergoes autophosphorylation of its tyrosine kinase domains, subsequently recruiting and activating key signaling molecules such as IRS-1, IRS-2, PI3K, and GRB2. These interactions are fundamental for the propagation of insulin′s pleiotropic effects, influencing processes like cell growth, differentiation, and metabolism. The precise localization of the insulin receptor on the cell membrane is vital for its function, as this allows for immediate and efficient transmission of insulin signals from the extracellular environment to the intracellular machinery. By targeting the beta subunit, Insulin Rβ (11B6) antibody enables researchers to investigate the dynamics of insulin receptor distribution, activation, and interaction with downstream signaling proteins, providing valuable insights into insulin signaling mechanisms and their implications in metabolic disorders such as Type 1 and Type 2 diabetes. Insulin Rβ (11B6) monoclonal antibody serves as an indispensable tool for researchers exploring these complex signaling pathways and the cellular localization of the insulin receptor, thereby advancing the development of therapeutic strategies for diabetes and related metabolic diseases.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-INSR/Insulin Receptor β Antibody (11B6 ) has 12 citations in a variety of scientific publications.

Primary antibodies like Anti-INSR/Insulin Receptor β Antibody (11B6 ) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

INSR/Insulin Receptor β Antibody (11B6 ) Specifications

Alternate Product Name: Insulin Receptor Beta

Product Clone Name: 11B6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: insulin R

Epitope Species: human

Product Reactivity/Detection: insulin Rβ

Species Reactivity/Detection: mouse, rat, human, canine

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 50 µg IgG₁ in 0.5 ml of PBS with < 0.1% sodium azide, 0.1% gelatin, PEG and sucrose

Research Citations: 12 citations in various scientific publications

Available Conjugates/Forms for INSR/Insulin Receptor β Antibody (11B6 ): N/A

The preferred INSR/Insulin Receptor β antibody is INSR/Insulin Receptor β Antibody (CT-3): sc-57342.