IL-6 Antibody (C12-1-hIL-6): sc-32296

IL-6 Antibody (C12-1-hIL-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects IL-6 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP). IL-6 (C12-1-hIL-6) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, providing versatility for different experimental needs. Interleukin-6, or IL-6, is a multifunctional cytokine composed of 212 amino acids that plays a pivotal role in immune response, inflammation, and hematopoiesis. IL-6 is primarily secreted by immune cells, including T cells and macrophages, and is crucial for the regulation of the acute phase response during infection and tissue injury. IL-6′s ability to induce fever and stimulate the production of acute phase proteins in the liver underscores its importance in host defense mechanisms. IL-6 achieves its effects by binding to a specific receptor that forms a trimeric complex, leading to the activation of intracellular signaling pathways, including the JAK/STAT pathway, which ultimately influences gene expression related to immune and inflammatory responses. Dynamic regulation of IL-6 is essential for maintaining homeostasis, and dysregulation of IL-6 signaling has been implicated in various pathological conditions, including autoimmune diseases and cancer, making IL-6 a significant target for therapeutic intervention.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

LI-COR^® and Odyssey^® are registered trademarks of LI-COR Biosciences

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-6 Antibody (C12-1-hIL-6) has 53 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-6 Antibody (C12-1-hIL-6) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-6 Antibody (C12-1-hIL-6) Specifications

Alternate Product Name: Interleukin 6

Product Clone Name: C12-1-hIL-6

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2a kappa light chain

Amino Acids:

Epitope Target: IL-6

Epitope Species: human

Product Reactivity/Detection: IL-6

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 200 µg IgG_2a kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 53 citations in various scientific publications

Available Conjugates/Forms for IL-6 Antibody (C12-1-hIL-6): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin

The preferred IL-6 antibody is IL-6 Antibody (E-4): sc-28343.