IL-6 Antibody (10E5): sc-57315

IL-6 Antibody (10E5) is a mouse monoclonal IgG2b kappa light chain antibody that detects IL-6 in mouse and rat samples through applications such as western blotting (WB), immunoprecipitation (IP), flow cytometry (FCM), and enzyme-linked immunosorbent assay (ELISA). Anti-IL-6 antibody (10E5) is available in a non-conjugated form, allowing for versatile experimental use. Interleukin-6, or IL-6, is a multifunctional cytokine composed of 212 amino acids, playing a pivotal role in various physiological processes, including immune response, inflammation, and hematopoiesis. IL-6 (10E5) monoclonal antibody recognizes a protein primarily secreted by immune cells, such as macrophages and T cells, crucial for regulating immune responses during infections and tissue injury. Notably, IL-6 is involved in the differentiation of B cells into antibody-producing plasma cells, highlighting its importance in adaptive immunity. Additionally, IL-6 acts as an endogenous pyrogen, influencing the fever response during bacterial infections, which is vital for host defense. The IL-6 receptor, a trimeric complex, consists of an IL-6-specific alpha chain and a homodimer of the gp130 glycoprotein, which is shared among several interleukin receptors. Upon IL-6 binding, the receptor complex activates associated kinases JAK1 and JAK2, leading to the phosphorylation of Stat3 and its subsequent translocation to the nucleus, where it drives the expression of genes involved in inflammation and immune regulation. The significance of IL-6 in both normal physiology and pathological conditions, such as chronic inflammation and autoimmune diseases, underscores the relevance of IL-6 (10E5) antibody in research and therapeutic applications.

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IL-6 Antibody (10E5) has 166 citations in a variety of scientific publications.

Primary antibodies like Anti-IL-6 Antibody (10E5) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IL-6 Antibody (10E5) Specifications

Alternate Product Name: Interleukin 6

Product Clone Name: 10E5

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids:

Epitope Target: IL-6

Epitope Species: rat

Product Reactivity/Detection: IL-6

Species Reactivity/Detection: mouse, rat

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, FCM, ELISA

Vialing Information: Each vial contains 100 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 166 citations in various scientific publications

Available Conjugates/Forms for IL-6 Antibody (10E5): N/A

The preferred IL-6 antibody is IL-6 Antibody (E-4): sc-28343.