IL-4 Antibody (CC311): sc-101845
- IL-4 Antibody (CC311) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against recombinant IL-4 of bovine origin
- recommended for detection of IL-4 of ovine and bovine origin by FCM and ELISA
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgG1 BP-HRP are the preferred secondary detection reagents for IL-4 Antibody (CC311). These reagents are now offered in bundles with IL-4 Antibody (CC311) (see ordering information below).
QUICK LINKS
SEE ALSO...
IL-4 Antibody (CC311) is a mouse monoclonal IgG1 antibody that detects interleukin-4 (IL-4) in ovine and bovine species by flow cytometry (FCM) and enzyme-linked immunosorbent assay (ELISA). IL-4 is a glycosylated cytokine secreted primarily by activated T lymphocytes, basophils, and mast cells, playing a crucial role in the immune response by promoting the growth and differentiation of immune cells. One of the key functions of IL-4 is inducing immunoglobulin class switching, which is vital for effective immune defense. Specifically, IL-4 stimulates B cells to produce immunoglobulin E (IgE) and enhances immunoglobulin G4 (IgG4) secretion, while simultaneously suppressing the production of other immunoglobulin classes such as IgM, IgA, IgG1, IgG2, and IgG3. This selective regulation of antibody production is essential for orchestrating appropriate immune responses, particularly in allergic reactions and responses to parasitic infections. Furthermore, the signaling pathway activated by IL-4 involves rapid tyrosine phosphorylation of Stat6, a transcription factor that mediates IL-4 effects on gene expression, thereby underscoring IL-4′s importance in shaping the immune landscape. Anti-IL-4 antibody (CC311) serves as an invaluable tool for researchers studying immune responses in ovine and bovine models.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-4 Antibody (CC311) References:
- IL-4 induces eotaxin in human dermal fibroblasts. | Mochizuki, M., et al. 1999. Int Arch Allergy Immunol. 120 Suppl 1: 19-23. PMID: 10529597
- IL-4 induces IL-13-independent allergic airway inflammation. | Perkins, C., et al. 2006. J Allergy Clin Immunol. 118: 410-9. PMID: 16890766
- Paradoxical roles of IL-4 in tumor immunity. | Li, Z., et al. 2009. Cell Mol Immunol. 6: 415-22. PMID: 20003817
- IL-4 Induces Cholinergic Differentiation of Retinal Cells In Vitro. | Granja, MG., et al. 2015. Cell Mol Neurobiol. 35: 689-701. PMID: 25682112
- Associations between polymorphisms in the IL-4 and IL-4 receptor genes and urinary carcinomas: a meta-analysis. | Luo, Y., et al. 2015. Int J Clin Exp Med. 8: 1227-33. PMID: 25785117
- CD300f associates with IL-4 receptor α and amplifies IL-4-induced immune cell responses. | Moshkovits, I., et al. 2015. Proc Natl Acad Sci U S A. 112: 8708-13. PMID: 26124135
- IL-4 regulates B-cell receptor signaling in CLL. | Efremov, DG. 2016. Blood. 128: 468-9. PMID: 27471231
- IL-4 Haploinsufficiency Specifically Impairs IgE Responses against Allergens in Mice. | Robinson, MJ., et al. 2017. J Immunol. 198: 1815-1822. PMID: 28115531
- TRAF6 promotes IL-4-induced M2 macrophage activation by stabilizing STAT6. | Zhou, C., et al. 2020. Mol Immunol. 127: 223-229. PMID: 33017719
- Functional significance of IL-4 receptor on B cells in IL-4-induced human IgE production. | Yanagihara, Y., et al. 1995. J Allergy Clin Immunol. 96: 1145-51. PMID: 8543771
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-4 Antibody (CC311) | sc-101845 | 200 µg/ml | $322.00 | |||
IL-4 Antibody (CC311): m-IgG Fc BP-HRP Bundle | sc-539792 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-4 Antibody (CC311): m-IgG1 BP-HRP Bundle | sc-541713 | 200 µg Ab; 20 µg BP | $361.00 | |||
IL-4 Antibody (CC311) FITC | sc-101845 FITC | 200 µg/ml | $336.00 | |||
IL-4 Antibody (CC311) PE | sc-101845 PE | 200 µg/ml | $349.00 |