IL-2Rα Antibody (BC96): sc-19628
- IL-2Rα Antibody (BC96) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 200 µg/ml
- raised against IL-2Rα of human origin
- recommended for detection of IL-2Rα of human origin by FCM
- available conjugated to either phycoerythrin, FITC, Alexa Fluor® 488 or Alexa Fluor® 647 for IF, IHC(P) and FCM
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for IL-2Rα Antibody (BC96). These reagents are now offered in bundles with IL-2Rα Antibody (BC96) (see ordering information below).
QUICK LINKS
SEE ALSO...
IL-2Rα Antibody (BC96) is a mouse monoclonal IgG1 antibody that detects IL-2Rα in human samples through flow cytometry (FCM). IL-2Rα, also known as CD25, plays a crucial role in the immune system by serving as a high-affinity receptor for interleukin-2 (IL-2), a key cytokine involved in T cell proliferation and differentiation. IL-2Rα expression on T cells is essential for their activation and survival, making IL-2Rα a critical component in immune responses, particularly in the context of T cell-mediated immunity and tolerance. Notably, IL-2Rα is predominantly expressed on activated T cells, regulatory T cells, and certain hematopoietic cells, which underscores IL-2Rα′s importance in modulating immune responses and maintaining homeostasis. IL-2Rα interaction with IL-2 not only promotes T cell growth but also influences the development of various immune cell types, thereby impacting overall immune function. Given IL-2Rα′s pivotal role in immune regulation, IL-2Rα serves as a significant marker for studying immune disorders, cancer immunotherapy, and the mechanisms of T cell activation.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
IL-2Rα Antibody (BC96) References:
- Modulation of IL-2Rα with daclizumab for treatment of multiple sclerosis. | Wiendl, H. and Gross, CC. 2013. Nat Rev Neurol. 9: 394-404. PMID: 23732529
- IL-2Rα mediates temporal regulation of IL-2 signaling and enhances immunotherapy. | Su, EW., et al. 2015. Sci Transl Med. 7: 311ra170. PMID: 26511507
- Tfr cells lack IL-2Rα but express decoy IL-1R2 and IL-1Ra and suppress the IL-1-dependent activation of Tfh cells. | Ritvo, PG., et al. 2017. Sci Immunol. 2: PMID: 28887367
- The activation of PPARγ enhances Treg responses through up-regulating CD36/CPT1-mediated fatty acid oxidation and subsequent N-glycan branching of TβRII/IL-2Rα. | Miao, Y., et al. 2022. Cell Commun Signal. 20: 48. PMID: 35392915
- IL-2/IL-2R signaling and IL-2Rα-targeted therapy in anaplastic large cell lymphoma. | Liang, HC. 2022. Pathologie (Heidelb). 43: 25-30. PMID: 36094651
- Proximity-enabled covalent binding of IL-2 to IL-2Rα selectively activates regulatory T cells and suppresses autoimmunity. | Zhang, B., et al. 2023. Signal Transduct Target Ther. 8: 28. PMID: 36690610
- IL-2Rα-biased agonist enhances antitumor immunity by invigorating tumor-infiltrating CD25+CD8+ T cells. | Wu, W., et al. 2023. Nat Cancer. 4: 1309-1325. PMID: 37550516
- Amniotic MSC affect CD8 naive polarization toward SLEC/MPEC subsets by down-modulating IL-12Rβ1 and IL-2Rα signaling pathways. | Papait, A., et al. 2023. iScience. 26: 108483. PMID: 38077154
- Cantharidin overcomes IL-2Rα signaling-mediated vorinostat resistance in cutaneous T-cell lymphoma through reactive oxygen species. | Zhu, M., et al. 2024. J Immunother Cancer. 12: PMID: 39004437
- A PD-1-targeted, receptor-masked IL-2 immunocytokine that engages IL-2Rα strengthens T cell-mediated anti-tumor therapies. | Wu, J., et al. 2024. Cell Rep Med. 5: 101747. PMID: 39326410
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
IL-2Rα Antibody (BC96) | sc-19628 | 200 µg/ml | $322.00 | |||
IL-2Rα Antibody (BC96): m-IgG Fc BP-HRP Bundle | sc-536624 | 200 µg Ab; 10 µg BP | $361.00 | |||
IL-2Rα Antibody (BC96): m-IgGκ BP-HRP Bundle | sc-533781 | 200 µg Ab; 40 µg BP | $361.00 | |||
IL-2Rα Antibody (BC96) Alexa Fluor® 488 | sc-19628 AF488 | 200 µg/ml | $364.00 | |||
IL-2Rα Antibody (BC96) Alexa Fluor® 647 | sc-19628 AF647 | 200 µg/ml | $364.00 | |||
IL-2Rα Antibody (BC96) FITC | sc-19628 FITC | 200 µg/ml | $336.00 | |||
IL-2Rα Antibody (BC96) PE | sc-19628 PE | 200 µg/ml | $349.00 |