IFN-γRα Antibody (D-3): sc-28363

IFN-γRα Antibody (D-3) is a mouse monoclonal IgG1 antibody that detects IFN-γRα in human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). IFN-γRα plays a crucial role in the immune response by serving as a receptor for interferon-gamma, a key cytokine involved in antiviral and immunomodulatory activities. IFN-γRα is primarily located on the surface of immune cells, where IFN-γRα facilitates the binding of interferon-gamma, leading to the activation of intracellular signaling pathways that promote the expression of genes involved in immune defense. This localization is vital because IFN-γRα ensures that immune cells can rapidly respond to infections and other immune challenges, thereby enhancing the body′s ability to fight off pathogens. IFN-γRα function depends on interaction with the IFN-γRβ chain, which is essential for receptor signaling capabilities. The proper assembly and function of this receptor complex are critical for the activation of downstream signaling molecules, such as Janus kinases and Stat proteins, which ultimately lead to the transcription of genes that mediate the immune response.

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IFN-γRα Antibody (D-3) References:

1. TaqI RFLP in the interferon gamma receptor 1 gene (IFNGR1) on human chromosome 6q.  |  Hauptschein, R., et al. 1992. Nucleic Acids Res. 20: 1158. PMID: 1372404
2. Interferon-gamma receptor-1 gene promoter polymorphisms (G-611A; T-56C) and susceptibility to tuberculosis.  |  Bulat-Kardum, L., et al. 2006. Scand J Immunol. 63: 142-50. PMID: 16476014
3. Type I IFNs downregulate myeloid cell IFN-γ receptor by inducing recruitment of an early growth response 3/NGFI-A binding protein 1 complex that silences ifngr1 transcription.  |  Kearney, SJ., et al. 2013. J Immunol. 191: 3384-92. PMID: 23935197
4. Deletion of the entire interferon-γ receptor 1 gene causing complete deficiency in three related patients.  |  de Vor, IC., et al. 2016. J Clin Immunol. 36: 195-203. PMID: 26931784
5. Missense splice variant (g.20746A>G, p.Ile183Val) of interferon gamma receptor 1 (IFNGR1) coincidental with mycobacterial osteomyelitis - a screen of osteoarticular lesions.  |  Bińczak-Kuleta, A., et al. 2016. Bosn J Basic Med Sci. 16: 215-21. PMID: 27356097
6. Ifngr1 and Stat1 mediated canonical Ifn-γ signaling drives nigrostriatal degeneration.  |  Strickland, MR., et al. 2018. Neurobiol Dis. 110: 133-141. PMID: 29196213
7. The Distribution Frequency of Interferon-Gamma Receptor 1 Gene Polymorphisms in Interferon-γ Release Assay-Positive Patients.  |  Chen, C., et al. 2017. Dis Markers. 2017: 4031671. PMID: 29209098
8. Early diagnosis of partial interferon-γ receptor 1 deficiency prevents the development of Bacille de Calmette et Guérin osteomyelitis.  |  Tomomasa, D., et al. 2022. Clin Immunol. 235: 108933. PMID: 35074548
9. Cancer cell-derived extracellular vesicles drive pre-metastatic niche formation of lymph node via IFNGR1/JAK1/STAT1-activated-PD-L1 expression on FRCs in head and neck cancer.  |  Han, N., et al. 2023. Oral Oncol. 145: 106524. PMID: 37482043
10. In Vitro Selection of Macrocyclic l-α/d-α/β/γ-Hybrid Peptides Targeting IFN-γ/IFNGR1 Protein-Protein Interaction.  |  Miura, T., et al. 2024. J Am Chem Soc. 146: 17691-17699. PMID: 38888290

The preferred IFN-γRα antibody is IFN-γRα Antibody (GIR-94): sc-12755.