I-FABP Antibody (G-1): sc-514641

I-FABP Antibody (G-1) is a mouse monoclonal IgG1 antibody that detects intestinal fatty acid-binding protein (I-FABP) in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). I-FABP is a crucial cytosolic protein predominantly found in the epithelial cells of the small intestine, where anti-I-FABP antibody (G-1) helps reveal its vital role in the absorption and transport of fatty acids, thereby influencing lipid metabolism and energy homeostasis. I-FABP′s ability to bind and transport fatty acids is essential for maintaining cellular lipid balance and supporting various metabolic processes, including the regulation of insulin sensitivity. Notably, the human I-FABP gene is located on chromosome 4q26 and exhibits a polymorphism at codon 54, resulting in two alleles: one encoding alanine and the other threonine. The threonine variant at this position has been linked to enhanced fat oxidation and a predisposition to insulin resistance, highlighting the importance of I-FABP in metabolic health. I-FABP monoclonal antibody (G-1) serves as an invaluable tool for researchers investigating the roles of fatty acid-binding proteins in metabolic disorders and related physiological processes.

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I-FABP Antibody (G-1) References:

1. I-FABP expression alters the intracellular distribution of the BODIPY C16 fatty acid analog.  |  Karsenty, J., et al. 2009. Mol Cell Biochem. 326: 97-104. PMID: 19125316
2. [Intestinal fatty acid-binding protein (I-FABP) as a new biomarker for intestinal diseases].  |  Funaoka, H., et al. 2010. Rinsho Byori. 58: 162-8. PMID: 20229815
3. I-FABP and L-FABP are early markers for abdominal injury with limited prognostic value for secondary organ failures in the post-traumatic course.  |  Voth, M., et al. 2015. Clin Chem Lab Med. 53: 771-80. PMID: 25324448
4. I-FABP as biomarker for the early diagnosis of acute mesenteric ischemia and resultant lung injury.  |  Khadaroo, RG., et al. 2014. PLoS One. 9: e115242. PMID: 25541714
5. Serum I-FABP Detects Gluten Responsiveness in Adult Celiac Disease Patients on a Short-Term Gluten Challenge.  |  Adriaanse, MP., et al. 2016. Am J Gastroenterol. 111: 1014-22. PMID: 27185075
6. I-FABP Is Higher in People With Chronic HIV Than Elite Controllers, Related to Sugar and Fatty Acid Intake and Inversely Related to Body Fat in People With HIV.  |  Cheru, LT., et al. 2018. Open Forum Infect Dis. 5: ofy288. PMID: 30515430
7. Intestinal fatty acid binding protein (I-FABP) and CXC3L1 evaluation as biomarkers for patients at high-risk for coeliac disease in Johannesburg, South Africa.  |  Gandini, A., et al. 2022. Cytokine. 157: 155945. PMID: 35841826
8. Increased levels of intestinal-type fatty acid-binding protein (I-FABP) in mood disorders.  |  Arnone, D. 2023. Psychol Med. 53: 4827-4828. PMID: 35861115
9. Measurements of I-FABP and citrulline in the postoperative period of non-cardiac surgeries with gastrointestinal complications: A prospective cohort observational study.  |  Ajeje, ET., et al. 2024. J Crit Care. 81: 154530. PMID: 38335862
10. Longitudinal analysis of urinary I-FABP in extremely preterm infants that develop necrotizing enterocolitis.  |  Fundora, JB., et al. 2024. Pediatr Res.. PMID: 39550515

The preferred I-FABP antibody is I-FABP Antibody (E-9): sc-374482.