I-FABP Antibody (E-9): sc-374482

I-FABP Antibody (E-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects I-FABP of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-I-FABP antibody (E-9) is available as the non-conjugated form. Intestinal fatty acid-binding protein (I-FABP) plays a crucial role in lipid metabolism, particularly in the absorption and transport of fatty acids within intestinal epithelial cells. I-FABP is predominantly located in the cytosol of enterocytes, where I-FABP facilitates fatty acid uptake from the intestinal lumen and subsequent transport to various cellular compartments for metabolism or storage. Efficient fatty acid transport is vital for maintaining energy homeostasis and supporting cellular functions, especially in tissues with high metabolic demands. The human I-FABP gene is located on chromosome 4q26 and exhibits a polymorphism at codon 54, resulting in two alleles: one encoding alanine and another encoding threonine. The threonine variant is associated with enhanced fat oxidation and insulin resistance, highlighting I-FABP′s importance in metabolic health and disease.

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I-FABP Antibody (E-9) References:

1. The fatty acid transport function of fatty acid-binding proteins.  |  Storch, J. and Thumser, AE. 2000. Biochim Biophys Acta. 1486: 28-44. PMID: 10856711
2. Unravelling the significance of cellular fatty acid-binding proteins.  |  Glatz, JF. and Storch, J. 2001. Curr Opin Lipidol. 12: 267-74. PMID: 11353329
3. Fatty acid-binding proteins of nervous tissue.  |  Veerkamp, JH. and Zimmerman, AW. 2001. J Mol Neurosci. 16: 133-42; discussion 151-7. PMID: 11478368
4. Urinary I-FABP, L-FABP, TFF-3, and SAA Can Diagnose and Predict the Disease Course in Necrotizing Enterocolitis at the Early Stage of Disease.  |  Coufal, S., et al. 2020. J Immunol Res. 2020: 3074313. PMID: 32190704
5. I-FABP is decreased in COVID-19 patients, independently of the prognosis.  |  Guedj, K., et al. 2021. PLoS One. 16: e0249799. PMID: 33857216
6. Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia.  |  Nuzzo, A., et al. 2021. Sci Rep. 11: 18929. PMID: 34556697
7. Could I-FABP Be an Early Marker of Celiac Disease in Children with Type 1 Diabetes? Retrospective Study from the Tertiary Reference Centre.  |  Ochocińska, A., et al. 2022. Nutrients. 14: PMID: 35276772
8. The Value of Serum I-FABP Level in the Diagnosis of Acute Appendicitis.  |  Cakal, N., et al. 2022. Clin Lab. 68: PMID: 35536089
9. I-FABP protein/mRNA and IL-6 as biomarkers of intestinal barrier dysfunction in neonates with necrotizing enterocolitis and SPF BALB/c mouse models.  |  Chen, J., et al. 2024. J Int Med Res. 52: 3000605241254788. PMID: 38867509
10. Cytoplasmic fatty acid-binding proteins: their structure and genes.  |  Veerkamp, JH. and Maatman, RG. 1995. Prog Lipid Res. 34: 17-52. PMID: 7644552
11. An amino acid substitution in the human intestinal fatty acid binding protein is associated with increased fatty acid binding, increased fat oxidation, and insulin resistance.  |  Baier, LJ., et al. 1995. J Clin Invest. 95: 1281-7. PMID: 7883976
12. Uncoupling of obesity from insulin resistance through a targeted mutation in aP2, the adipocyte fatty acid binding protein.  |  Hotamisligil, GS., et al. 1996. Science. 274: 1377-9. PMID: 8910278

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-I-FABP Antibody (E-9) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-I-FABP Antibody (E-9) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

I-FABP Antibody (E-9) Specifications

Alternate Product Name: FABP2

Product Clone Name: E-9

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 101-129

Epitope Target: I-FABP

Epitope Species: human

Product Reactivity/Detection: I-FABP

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for I-FABP Antibody (E-9): P: Blocking Peptide