HYAL3 Antibody (E-4): sc-374036
- HYAL3 Antibody (E-4) is a mouse monoclonal IgG2b κ HYAL3 antibody provided at 200 µg/ml
- raised against amino acids 72-132 mapping within an internal region of HYAL3 of mouse origin
- HYAL3 Antibody (E-4) is recommended for detection of HYAL3 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-HYAL3 Antibody (E-4) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for HYAL3 Antibody (E-4) for WB and IHC(P) applications. These reagents are now offered in bundles with HYAL3 Antibody (E-4) (see ordering information below).
QUICK LINKS
HYAL3 Antibody (E-4) is a mouse monoclonal IgG2b kappa light chain antibody that detects HYAL3 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). Anti-HYAL3 antibody (E-4) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HYAL3, a member of the hyaluronidase family, plays a significant role in the degradation of hyaluronic acid, a vital component of the extracellular matrix that maintains tissue hydration and supports cellular functions such as proliferation and differentiation. HYAL3 is predominantly expressed in the testis and bone marrow, highlighting its potential importance in reproductive and hematopoietic processes. While other hyaluronidases have been implicated in cancer progression, HYAL3 is not considered a tumor suppressor due to the absence of mutations in its gene, suggesting a unique role in cellular homeostasis rather than in tumorigenesis. HYAL3′s ability to modulate the extracellular matrix environment may have implications for understanding its function in both normal physiology and disease states, making HYAL3 (E-4) antibody a valuable tool for researchers studying these processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HYAL3 Antibody (E-4) References:
- Mutations in HYAL1, a member of a tandemly distributed multigene family encoding disparate hyaluronidase activities, cause a newly described lysosomal disorder, mucopolysaccharidosis IX. | Triggs-Raine, B., et al. 1999. Proc Natl Acad Sci U S A. 96: 6296-300. PMID: 10339581
- The six hyaluronidase-like genes in the human and mouse genomes. | Csoka, AB., et al. 2001. Matrix Biol. 20: 499-508. PMID: 11731267
- Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3. | Shuttleworth, TL., et al. 2002. J Biol Chem. 277: 23008-18. PMID: 11929860
- Assignment of the porcine hyaluronidase-3 (HYAL3) gene to SSC13-->q21 by FISH and confirmation by hybrid panel analyses. | Gatphayak, K., et al. 2003. Cytogenet Genome Res. 101: 178. PMID: 14619892
- Molecular characterization of porcine hyaluronidase genes 1, 2, and 3 clustered on SSC13q21. | Gatphayak, K., et al. 2004. Cytogenet Genome Res. 106: 98-106. PMID: 15218248
- Hyaluronidase expression in cultured growth plate chondrocytes during differentiation. | Tanimoto, K., et al. 2004. Cell Tissue Res. 318: 335-42. PMID: 15503157
- The over-expression of HAS2, Hyal-2 and CD44 is implicated in the invasiveness of breast cancer. | Udabage, L., et al. 2005. Exp Cell Res. 310: 205-17. PMID: 16125700
- Expression profile of hyaluronidase mRNA transcripts in the kidney and in renal cells. | Sun, L., et al. 1998. Kidney Blood Press Res. 21: 413-8. PMID: 9933825
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HYAL3 Antibody (E-4) | sc-374036 | 200 µg/ml | $316.00 | |||
HYAL3 Antibody (E-4): m-IgG Fc BP-HRP Bundle | sc-529642 | 200 µg Ab; 10 µg BP | $354.00 | |||
HYAL3 Antibody (E-4): m-IgGκ BP-HRP Bundle | sc-522597 | 200 µg Ab, 40 µg BP | $354.00 | |||
HYAL3 Antibody (E-4): m-IgG2b BP-HRP Bundle | sc-550135 | 200 µg Ab; 10 µg BP | $354.00 | |||
HYAL3 Antibody (E-4) AC | sc-374036 AC | 500 µg/ml, 25% agarose | $416.00 | |||
HYAL3 Antibody (E-4) HRP | sc-374036 HRP | 200 µg/ml | $316.00 | |||
HYAL3 Antibody (E-4) FITC | sc-374036 FITC | 200 µg/ml | $330.00 | |||
HYAL3 Antibody (E-4) PE | sc-374036 PE | 200 µg/ml | $343.00 | |||
HYAL3 Antibody (E-4) Alexa Fluor® 488 | sc-374036 AF488 | 200 µg/ml | $357.00 | |||
HYAL3 Antibody (E-4) Alexa Fluor® 546 | sc-374036 AF546 | 200 µg/ml | $357.00 | |||
HYAL3 Antibody (E-4) Alexa Fluor® 594 | sc-374036 AF594 | 200 µg/ml | $357.00 | |||
HYAL3 Antibody (E-4) Alexa Fluor® 647 | sc-374036 AF647 | 200 µg/ml | $357.00 | |||
HYAL3 Antibody (E-4) Alexa Fluor® 680 | sc-374036 AF680 | 200 µg/ml | $357.00 | |||
HYAL3 Antibody (E-4) Alexa Fluor® 790 | sc-374036 AF790 | 200 µg/ml | $357.00 |