HYAL3 Activators
HYAL3 Activators belong to a distinctive chemical class characterized by their ability to modulate the activity of the hyaluronidase 3 (HYAL3) enzyme. HYAL3 is a member of the hyaluronidase family, enzymes that play a crucial role in the degradation and remodeling of hyaluronic acid (HA), a key component of the extracellular matrix in various tissues. These activators exert their influence by specifically interacting with HYAL3, ultimately regulating its enzymatic function. Hyaluronidases, including HYAL3, are responsible for breaking down HA polymers into smaller fragments, impacting tissue structure and cellular behavior. By modulating HYAL3 activity, these activators contribute to the intricate balance of HA turnover, influencing cellular processes such as cell migration, proliferation, and adhesion.
Structurally, HYAL3 Activators are designed to interact with the catalytic site of HYAL3, affecting the enzyme's ability to cleave HA chains. This interaction can occur through various mechanisms, including competitive binding or allosteric modulation. The specificity of these activators for HYAL3 sets them apart from other hyaluronidase modulators, highlighting their potential as targeted tools for studying the physiological roles of HYAL3 and the broader impact of hyaluronidase activity on cellular microenvironments. Understanding the intricate regulation of hyaluronidases, particularly HYAL3, can shed light on fundamental processes in development, tissue homeostasis, and disease progression, making HYAL3 Activators valuable tools for unraveling the intricacies of hyaluronan metabolism and its impact on cellular physiology.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Hyaluronic acid | 9004-61-9 | sc-337865 | 10 mg | $208.00 | ||
Hyaluronan is a glycosaminoglycan that can bind to HYAL3, enhancing its enzymatic activity to degrade hyaluronic acid, which could result in increased turnover and recycling of extracellular matrix components and facilitate cell migration and proliferation. | ||||||
4-Methylumbelliferone | 90-33-5 | sc-206910 sc-206910A sc-206910B sc-206910C sc-206910D | 25 g 100 g 250 g 1 kg 2.5 kg | $35.00 $56.00 $141.00 $431.00 $973.00 | 2 | |
4-Methylumbelliferone is an inhibitor of hyaluronan synthesis. By reducing the substrate availability, HYAL3 activity can be indirectly enhanced as the cellular response may upregulate HYAL3 expression to compensate for lower hyaluronan levels. | ||||||
Benzamidine | 618-39-3 | sc-233933 | 10 g | $292.00 | 1 | |
Benzamidine is a competitive inhibitor of serine proteases. By inhibiting proteases that may degrade HYAL3, it can enhance the stability and activity of HYAL3 in the extracellular matrix. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates protein kinase C (PKC), which can phosphorylate and activate various enzymes. PKC activation could enhance HYAL3 function indirectly by phosphorylation or by promoting a cellular environment that requires increased hyaluronidase activity. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid influences gene expression and can lead to the upregulation of enzymes involved in the metabolism of extracellular matrix components, potentially enhancing the activity of HYAL3 as part of the regulatory network. | ||||||
Glycyrrhizic acid | 1405-86-3 | sc-279186 sc-279186A | 1 g 25 g | $57.00 $333.00 | 7 | |
Glycyrrhizin inhibits hyaluronidase enzymes indirectly by binding to hyaluronic acid, protecting it from degradation. This can lead to a compensatory increase in HYAL3 activity to maintain homeostasis of hyaluronic acid levels. | ||||||
Chondroitin Sulfate, Bovine | 9007-28-7 | sc-203888 | 5 g | $94.00 | 1 | |
As a component of the extracellular matrix, chondroitin sulfate competes with hyaluronic acid for HYAL3 binding. The presence of chondroitin sulfate can enhance HYAL3 activity by increasing its substrate specificity for hyaluronic acid. | ||||||
Concanavalin A | 11028-71-0 | sc-203007 sc-203007A sc-203007B | 50 mg 250 mg 1 g | $119.00 $364.00 $947.00 | 17 | |
Concanavalin A is a lectin that can bind to sugar moieties on proteins. It may cluster glycoproteins like HYAL3, potentially enhancing its stability and enzymatic activity in the extracellular matrix. | ||||||
L-Ascorbic acid, free acid | 50-81-7 | sc-202686 | 100 g | $46.00 | 5 | |
Ascorbic acid is known to stabilize and enhance the synthesis of collagen in the extracellular matrix, which may indirectly enhance the activity of HYAL3 by altering the matrix composition and increasing the need for hyaluronidase activity. | ||||||
Manganese(II) chloride beads | 7773-01-5 | sc-252989 sc-252989A | 100 g 500 g | $19.00 $31.00 | ||
Manganese ions are cofactors for many enzymes, including hyaluronidases. Supplementing with manganese(II) chloride can enhance HYAL3 activity by providing necessary cofactors for optimal enzyme function. | ||||||