Huntingtin Antibody (HDC8A4): sc-58536
- Huntingtin Antibody (HDC8A4) is a mouse monoclonal mouse IgG1 κ κ provided at 200 µg/ml
- raised against amino acids 2703-2911 of Huntingtin of human origin
- recommended for detection of an epitope corresponding to the HDC region of the Huntingtin protein of mouse, rat and human origin by WB, IP and IF
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for Huntingtin Antibody (HDC8A4) for WB applications. These reagents are now offered in bundles with Huntingtin Antibody (HDC8A4) (see ordering information below).
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Huntingtin Antibody (HDC8A4) is a mouse monoclonal IgG1 antibody that detects Huntingtin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Huntingtin is a crucial protein that plays a significant role in neuronal function and survival, and proper functioning is vital for maintaining cellular health. Huntingtin (HDC8A4) antibody primarily detects targets in the cytoplasm and nucleus, where Huntingtin is involved in various cellular processes, including intracellular transport and transcriptional regulation. Huntingtin′s localization enables interaction with other cellular components, facilitating essential signaling pathways and cellular responses. Notably, Huntingtin′s interaction with proteins such as HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), and HIP1 underscores a role in maintaining cellular integrity and function. Dysregulation of these interactions, especially in the context of expanded polyglutamine repeats associated with Huntington′s disease, can lead to neurodegeneration and cellular dysfunctions. Anti-Huntingtin antibody (HDC8A4) serves as an invaluable tool for researchers studying molecular mechanisms underlying Huntington′s disease and related neurodegenerative disorders.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Huntingtin Antibody (HDC8A4) | sc-58536 | 200 µg/ml | $316.00 | |||
Huntingtin Antibody (HDC8A4): m-IgG Fc BP-HRP Bundle | sc-537150 | 200 µg Ab; 10 µg BP | $354.00 | |||
Huntingtin Antibody (HDC8A4): m-IgGκ BP-HRP Bundle | sc-534345 | 200 µg Ab; 40 µg BP | $354.00 | |||
Huntingtin Antibody (HDC8A4): m-IgG1 BP-HRP Bundle | sc-545037 | 200 µg Ab; 20 µg BP | $354.00 |