Huntingtin Antibody (3H2242): sc-71287

Huntingtin Antibody (3H2242) is a mouse monoclonal IgG1 antibody that detects Huntingtin in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). Huntingtin is a crucial protein that plays a significant role in neuronal function and survival, and proper functioning is vital for maintaining cellular health. Huntingtin is primarily located in the cytoplasm and nucleus, where Huntingtin is involved in various cellular processes, including intracellular transport and transcriptional regulation. This localization is particularly important because Huntingtin can interact with other cellular components, facilitating essential signaling pathways that prevent neurodegeneration. Notably, Huntingtin interacts with several key proteins, including HAP1, glyceraldehyde phosphate dehydrogenase (GAPDH), and HIP1, which are involved in synaptic function and cellular metabolism. Dysregulation of these interactions, especially in the context of the expanded polyglutamine region associated with Huntington′s disease, can lead to detrimental effects on neuronal health and contribute to the pathogenesis of neurodegenerative disorders. Anti-Huntingtin antibody (3H2242) is an invaluable tool for researchers studying the molecular mechanisms underlying Huntington′s disease and related conditions, providing insights into Huntingtin′s function and interactions within the cellular environment.

The preferred Huntingtin antibody is Huntingtin Antibody (3E10): sc-47757.